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Table 2 Stratified analysis of the CYP2E1 RsaI/PstI polymorphism and HNSCC

From: The PstI/RsaI and DraI polymorphisms of CYP2E1and head and neck cancer risk: a meta-analysis based on 21 case-control studies

Sub-grouped studies

Genetic model

No.of Studies

No.Cases/No.Controls

Test of association

Test of heterogeneity

    

OR (95% CI)

P

Q

P Q

I 2

Overall

c2 carriers vs. wild

21

4892/5995

1.02(0.90-1.17)

0.68

31.37

0.05

36.26

 

c2 homozygotes vs. wild

17

3920/5008

1.96(1.33-2.90)

<0.001

9.84

0.87

0

 

Dominant

21

4892/5995

1.08(0.95-1.22)

0.23

30.68

0.06

34.81

Asians

c2 carriers vs. wild

6

981/1291

1.03(0.86-1.24)

0.69

5.95

0.31

16.01

 

c2 homozygotes vs. wild

6

981/1291

2.08(1.34-3.23)

<0.001

4.17

0.52

0

 

Dominant

6

981/1291

1.12(0.94-1.33)

0.18

4.76

0.44

0

Caucasians

c2 carriers vs. wild

15

3911/4704

1.07(0.82-1.40)

0.57

25.40

0.03

44.89

 

c2 homozygotes vs. wild

11

2939/3717

1.58(0.68-3.68)

0.28

5.35

0.86

0

 

Dominant

15

3911/4704

1.03(0.86-1.24)

0.49

25.49

0.03

45.09

High quality

c2 carriers vs. wild

16

3914/4688

1.08(0.86-1.35)

0.48

26.49

0.033

43.38

 

c2 homozygotes vs. wild

13

3173/3913

1.81(1.13-2.89)

0.013

5.76

0.92

0

 

Dominant

16

3914/4688

1.11(0.90-1.37)

0.29

24.09

0.064

37.74

Low quality

c2 carriers vs. wild

5

978/1307

1.07(0.84-1.36)

0.57

4.71

0.31

15.11

 

c2 homozygotes vs. wild

4

747/1095

2.36(1.16-4.79)

0.017

3.70

0.29

19.04

 

Dominant

5

978/1307

1.12(0.81-1.55)

0.46

6.38

0.17

37.39

Ever-smokers

c2 carriers vs. wild

5

1173/831

0.62(0.34-1.12)

0.11

8.67

0.07

53.88

 

c2 homozygotes vs. wild

2

385/325

0.47(0.15-1.47)

0.19

0.10

0.74

0

 

Dominant

5

1173/831

0.61(0.33-1.11)

0.10

8.93

0.063

55.19

Never-smokers

c2 carriers vs. wild

4

549/677

1.40(0.93-2.11)

0.09

0.44

0.93

0

 

c2 homozygotes vs. wild

3

441/431

3.25(0.48-21.70)

0.22

3.66

0.16

45.43

 

Dominant

4

549/677

1.45(0.98-2.16)

0.06

1.19

0.75

0

Alcohol- drinkers

c2 carriers vs. wild

4

565/467

1.12(0.51-2.43)

0.76

8.39

0.039

64.26

 

c2 homozygotes vs. wild

2

198/296

1.48(0.34-6.44)

0.59

0.83

0.36

0

 

Dominant

4

565/467

1.11(0.53-2.29)

0.77

7.58

0.055

60.43

Non-drinkers

c2 carriers vs. wild

3

653/883

0.92(0.64-1.33)

0.69

1.31

0.51

0

 

c2 homozygotes vs. wild

2

443/370

2.22(0.93-5.30)

0.07

0.004

0.94

0

 

Dominant

3

653/883

1.07(0.76-1.52)

0.67

1.08

0.58

0

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