Figure 8From: Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype Effects of dasatinib and Eto on cell cycle progression and induction of apoptosis in MDA-MB-231 cells. The cells were treated with 0.1 μM Eto and/or 0.1 μM dasatinib for two days, and cell cycle and apoptosis were measured as described in the Materials and Methods. Dasatinib induced a G1-S blockade with a slight apoptosis, Eto induced a G2-M accumulation, and the combined treatment induced a G1-S blockade with a slight apoptosis in MDA-MB-231 cells.Back to article page