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Table 5 Limiting Toxicity Syndromes (LTS): overall and in young-elderly patients

From: "Poker" association of weekly alternating 5-fluorouracil, irinotecan, bevacizumab and oxaliplatin (FIr-B/FOx) in first line treatment of metastatic colorectal cancer: a phase II study

 

Overall

Young-elderly

 

N.

%

N.

%

Patients

50

100

24

100

Limiting Toxicity Syndromes (LTS)

22

44

11

46

LTS single-site (LTS-ss)

10

20

2

8

LTS multiple-sites (LTS-ms)

12

24

9

37.5

   Single DLT plus G2-3

10

20

7

29

   Double DLTs

2

4

2

8

  1. Abbreviation: DLT, dose-limiting toxicity; G, grade.