Table 4 Cumulative toxicity
| Â | Patients | Cycles | ||||||
|---|---|---|---|---|---|---|---|---|
Number | 50 | 247 | ||||||
NCI-CTC Grade | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Nausea (%) | 23 (46) | 15 (30) | 3 (6) | - | 81 (33) | 23 (9) | 4 (2) | - |
Vomiting (%) | 10 (20) | 6 (12) | 2 (4) | - | 19 (8) | 9 (4) | 2 (1) | - |
Diarrhea (%) | 20 (40) | 12(24) | 14 (28) | - | 76 (30) | 28 (11) | 15 (6) | - |
Hypoalbuminemia (%) | 2 (4) | 1 (2) | - | - | 2 (1) | 1 (0.5) | - | - |
Constipation (%) | 17 (34) | 1 (2) | - | - | 22 (9) | 1 (0.5) | - | - |
Stomatitis/mucositis (%) | 16 (32) | 2 (4) | 3 (6) | - | 29 (12) | 3 (1) | 3 (1) | - |
Erythema (%) | 1 (2) | - | 1 (2) | - | 3 (1) | - | 1 (0.5) | - |
Asthenia (%) | 13 (26) | 20 (40) | 3 (6) | - | 48 (19) | 38 (15) | 3 (1) | - |
Neurotoxicity (%) | 36(72) | 5 (10) | - | - | 126(51) | 6 (2) | - | - |
Hypertension (%) | 15 (30) | 4 (8) | 1 (2) | - | 27 (11) | 4 (2) | 1 (0.5) | - |
Hypotension (%) | 1 (2) | - | - | - | 1 (0.5) | - | - | - |
Hematuria (%) | 2 (4) | 1 (2) | - | - | 3 (1) | 1 (0.5) | - | - |
Gengival recession/gengivitis (%) | 7 (14) | - | - | - | 10 (4) | - | - | - |
Rhinitis (%) | 38 (76) | - | - | - | 110(44.5) | - | - | - |
Epistaxis (%) | 31 (62) | 2 (4) | - | - | 68 (27.5) | 2 (1) | - | - |
HFS (%) | 2 (4) | - | - | - | 2 (1) | - | - | - |
Headache (%) | 6 (12) | - | - | - | 9 (4) | - | - | - |
Hypokalemia (%) | 3 (6) | - | 1 (2) | - | 3 (1) | - | 1 (0.5) | - |
Hypertransaminasemy (%) | 3 (6) | 2 (4) | 1 (2) | 1 (2) | 9 (4) | 6 (2) | 1 (0.5) | 1 (0.5) |
Hyperpigmentation (%) | 6 (12) | 2 (4) | - | - | 14 (6) | 5 (2) | - | - |
Fever without infection (%) | 10 (20) | - | - | - | 10 (4) | - | - | - |
Alopecia (%) | 5 (10) | 9 (18) | 3 (6) | - | 11 (4) | 17 (7) | 7 (3) | - |
Anemia (%) | 7 (14) | 4 (8) | - | - | 16 (6) | 4 (2) | - | - |
Leucopenia (%) | 13 (26) | 17 (34) | - | - | 49 (20) | 26 (10.5) | - | - |
Neutropenia (%) | 9 (18) | 14 (28) | 5 (10) | - | 35 (14) | 32 (13) | 8 (3) | - |
Thrombocytopenia (%) | 7 (14) | 1 (2) | - | - | 16 (6) | 1 (0.5) | - | - |