TY - JOUR AU - Fisher, B. AU - Costantino, J. P. AU - Wickerham, D. L. AU - Redmond, C. K. AU - Kavanah, M. AU - Cronin, W. M. AU - Vogel, V. AU - Robidoux, A. AU - Dimitrov, N. AU - Atkins, J. PY - 1998 DA - 1998// TI - Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study JO - J Natl Cancer Inst VL - 90 UR - https://doi.org/10.1093/jnci/90.18.1371 DO - 10.1093/jnci/90.18.1371 ID - Fisher1998 ER - TY - JOUR AU - Rutqvist, L. E. AU - Johansson, H. AU - Signomklao, T. AU - Johansson, U. AU - Fornander, T. AU - Wilking, N. PY - 1995 DA - 1995// TI - Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. Stockholm Breast Cancer Study Group JO - J Natl Cancer Inst VL - 87 UR - https://doi.org/10.1093/jnci/87.9.645 DO - 10.1093/jnci/87.9.645 ID - Rutqvist1995 ER - TY - JOUR AU - Cuzick, J. AU - Powles, T. AU - Veronesi, U. AU - Forbes, J. AU - Edwards, R. AU - Ashley, S. AU - Boyle, P. PY - 2003 DA - 2003// TI - Overview of the main outcomes in breast-cancer prevention trials JO - Lancet VL - 361 UR - https://doi.org/10.1016/S0140-6736(03)12342-2 DO - 10.1016/S0140-6736(03)12342-2 ID - Cuzick2003 ER - TY - JOUR AU - Shang, Y. AU - Brown, M. PY - 2002 DA - 2002// TI - Molecular determinants for the tissue specificity of SERMs JO - Science VL - 295 UR - https://doi.org/10.1126/science.1068537 DO - 10.1126/science.1068537 ID - Shang2002 ER - TY - JOUR AU - Clemens, J. A. AU - Bennett, D. R. AU - Black, L. J. AU - Jones, C. D. PY - 1983 DA - 1983// TI - Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen induced mammary tumors and on LH and prolactin levels JO - Life Sci VL - 32 UR - https://doi.org/10.1016/0024-3205(83)90323-5 DO - 10.1016/0024-3205(83)90323-5 ID - Clemens1983 ER - TY - JOUR AU - Gottardis, M. M. AU - Jordan, V. C. PY - 1987 DA - 1987// TI - Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model JO - Cancer Res VL - 47 ID - Gottardis1987 ER - TY - JOUR AU - Anzano, M. A. AU - Peer, C. W. AU - Smith, J. M. AU - Mullen, L. T. AU - Shrader, M. W. AU - Logsdon, D. L. AU - Driver, C. L. AU - Brown, C. C. AU - Roberts, A. B. AU - Sporn, M. B. PY - 1996 DA - 1996// TI - Chemoprevention of mammary carcinogenesis in the rat: combined use of raloxifene and 9-cis-retinoic acid JO - J Natl Cancer Inst VL - 88 UR - https://doi.org/10.1093/jnci/88.2.123 DO - 10.1093/jnci/88.2.123 ID - Anzano1996 ER - TY - JOUR AU - Janakiram, N. B. AU - Steele, V. E. AU - Rao, C. V. PY - 2009 DA - 2009// TI - Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats JO - Cancer Prev Res (Phila Pa) VL - 2 UR - https://doi.org/10.1158/1940-6207.CAPR-08-0140 DO - 10.1158/1940-6207.CAPR-08-0140 ID - Janakiram2009 ER - TY - JOUR AU - Vogel, V. G. PY - 2009 DA - 2009// TI - The NSABP Study of Tamoxifen and Raloxifene (STAR) trial JO - Expert Rev Anticancer Ther VL - 9 UR - https://doi.org/10.1586/14737140.9.1.51 DO - 10.1586/14737140.9.1.51 ID - Vogel2009 ER - TY - JOUR AU - Cummings, S. R. AU - Eckert, S. AU - Krueger, K. A. AU - Grady, D. AU - Powles, T. J. AU - Cauley, J. A. AU - Norton, L. AU - Nickelsen, T. AU - Bjarnason, N. H. AU - Morrow, M. PY - 1999 DA - 1999// TI - The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation JO - Jama VL - 281 UR - https://doi.org/10.1001/jama.281.23.2189 DO - 10.1001/jama.281.23.2189 ID - Cummings1999 ER - TY - JOUR AU - Martino, S. AU - Cauley, J. A. AU - Barrett-Connor, E. AU - Powles, T. J. AU - Mershon, J. AU - Disch, D. AU - Secrest, R. J. AU - Cummings, S. R. PY - 2004 DA - 2004// TI - Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene JO - J Natl Cancer Inst VL - 96 UR - https://doi.org/10.1093/jnci/djh319 DO - 10.1093/jnci/djh319 ID - Martino2004 ER - TY - JOUR AU - Barrett-Connor, E. AU - Mosca, L. AU - Collins, P. AU - Geiger, M. J. AU - Grady, D. AU - Kornitzer, M. AU - McNabb, M. A. AU - Wenger, N. K. PY - 2006 DA - 2006// TI - Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women JO - N Engl J Med VL - 355 UR - https://doi.org/10.1056/NEJMoa062462 DO - 10.1056/NEJMoa062462 ID - Barrett-Connor2006 ER - TY - JOUR AU - Lee, W. L. AU - Cheng, M. H. AU - Chao, H. T. AU - Wang, P. H. PY - 2008 DA - 2008// TI - The role of selective estrogen receptor modulators on breast cancer: from tamoxifen to raloxifene JO - Taiwan J Obstet Gynecol VL - 47 UR - https://doi.org/10.1016/S1028-4559(08)60051-0 DO - 10.1016/S1028-4559(08)60051-0 ID - Lee2008 ER - TY - JOUR AU - Kuroishi, T. AU - Tominaga, S. PY - 2001 DA - 2001// TI - Epidemiol. Breast Cancer JO - Jpn J Cancer Chemother VL - 28 ID - Kuroishi2001 ER - TY - JOUR AU - Shibata, M. A. AU - Morimoto, J. AU - Otsuki, Y. PY - 2002 DA - 2002// TI - Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation JO - Cancer Gene Ther VL - 9 UR - https://doi.org/10.1038/sj.cgt.7700415 DO - 10.1038/sj.cgt.7700415 ID - Shibata2002 ER - TY - JOUR AU - Shibata, M. A. AU - Ito, Y. AU - Morimoto, J. AU - Otsuki, Y. PY - 2004 DA - 2004// TI - Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism JO - Carcinogenesis VL - 25 UR - https://doi.org/10.1093/carcin/bgh201 DO - 10.1093/carcin/bgh201 ID - Shibata2004 ER - TY - JOUR AU - Shibata, M. A. AU - Morimoto, J. AU - Shibata, E. AU - Otsuki, Y. PY - 2008 DA - 2008// TI - Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model JO - Cancer Gene Ther VL - 15 UR - https://doi.org/10.1038/cgt.2008.43 DO - 10.1038/cgt.2008.43 ID - Shibata2008 ER - TY - JOUR AU - Shibata, M. A. AU - Shibata, E. AU - Morimoto, J. AU - Eid, N. A. S. AU - Tanaka, Y. AU - Watanabe, M. AU - Otsuki, Y. PY - 2009 DA - 2009// TI - An immunocompetent murine model of metastatic mammary cancer accessible to bioluminescence imaging JO - Anticancer Res VL - 29 ID - Shibata2009 ER - TY - JOUR AU - Shibata, M. A. AU - Liu, M. L. AU - Knudson, M. C. AU - Shibata, E. AU - Yoshidome, K. AU - Bandy, T. AU - Korsmeyer, S. J. AU - Green, J. E. PY - 1999 DA - 1999// TI - Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage JO - EMBO J VL - 18 UR - https://doi.org/10.1093/emboj/18.10.2692 DO - 10.1093/emboj/18.10.2692 ID - Shibata1999 ER - TY - JOUR AU - Yoshimori, A. AU - Sakai, J. AU - Sunaga, S. AU - Kobayashi, T. AU - Takahashi, S. AU - Okita, N. AU - Takasawa, R. AU - Tanuma, S. PY - 2007 DA - 2007// TI - Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO JO - BMC Pharmacol VL - 7 UR - https://doi.org/10.1186/1471-2210-7-8 DO - 10.1186/1471-2210-7-8 ID - Yoshimori2007 ER - TY - JOUR AU - Tanuma, S. AU - Yoshimori, A. AU - Takasawa, R. PY - 2004 DA - 2004// TI - Genomic drug discovery for apoptosis regulation using a new computer screening amino acid complement wave method JO - Biol Pharm Bull VL - 27 UR - https://doi.org/10.1248/bpb.27.968 DO - 10.1248/bpb.27.968 ID - Tanuma2004 ER - TY - JOUR AU - Shibata, M. A. AU - Akao, Y. AU - Shibata, E. AU - Nozawa, Y. AU - Ito, T. AU - Mishima, S. AU - Morimoto, J. AU - Otsuki, Y. PY - 2007 DA - 2007// TI - Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation JO - Cancer Chemother Pharmacol VL - 60 UR - https://doi.org/10.1007/s00280-007-0414-y DO - 10.1007/s00280-007-0414-y ID - Shibata2007 ER - TY - JOUR AU - O'Regan, R. M. AU - Osipo, C. AU - Ariazi, E. AU - Lee, E. S. AU - Meeke, K. AU - Morris, C. AU - Bertucci, A. AU - Sarker, M. A. AU - Grigg, R. AU - Jordan, V. C. PY - 2006 DA - 2006// TI - Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice JO - Clin Cancer Res VL - 12 UR - https://doi.org/10.1158/1078-0432.CCR-05-2584 DO - 10.1158/1078-0432.CCR-05-2584 ID - O'Regan2006 ER - TY - JOUR AU - Gorrin-Rivas, M. J. AU - Arii, S. AU - Furutani, M. AU - Mizumoto, M. AU - Mori, A. AU - Hanaki, K. AU - Maeda, M. AU - Furuyama, H. AU - Kondo, Y. AU - Imamura, M. PY - 2000 DA - 2000// TI - Mouse macrophage metalloelastase gene transfer into a murine melanoma suppresses primary tumor growth by halting angiogenesis JO - Clin Cancer Res VL - 6 ID - Gorrin-Rivas2000 ER - TY - JOUR AU - Livak, K. J. AU - Schmittgen, T. D. PY - 2001 DA - 2001// TI - Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method JO - Methods VL - 25 UR - https://doi.org/10.1006/meth.2001.1262 DO - 10.1006/meth.2001.1262 ID - Livak2001 ER - TY - JOUR AU - Lee, L. M. AU - Cao, J. AU - Deng, H. AU - Chen, P. AU - Gatalica, Z. AU - Wang, Z. Y. PY - 2008 DA - 2008// TI - ER-alpha36, a novel variant of ER-alpha, is expressed in ER-positive and -negative human breast carcinomas JO - Anticancer Res VL - 28 ID - Lee2008 ER - TY - JOUR AU - Musgrove, E. A. AU - Sutherland, R. L. PY - 2009 DA - 2009// TI - Biological determinants of endocrine resistance in breast cancer JO - Nat Rev Cancer VL - 9 UR - https://doi.org/10.1038/nrc2713 DO - 10.1038/nrc2713 ID - Musgrove2009 ER - TY - JOUR AU - Simoncini, T. AU - Genazzani, A. R. AU - Liao, J. K. PY - 2002 DA - 2002// TI - Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene JO - Circulation VL - 105 UR - https://doi.org/10.1161/hc1102.105267 DO - 10.1161/hc1102.105267 ID - Simoncini2002 ER - TY - JOUR AU - Yang, N. N. AU - Venugopalan, M. AU - Hardikar, S. AU - Glasebrook, A. PY - 1996 DA - 1996// TI - Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene JO - Science VL - 273 UR - https://doi.org/10.1126/science.273.5279.1222 DO - 10.1126/science.273.5279.1222 ID - Yang1996 ER - TY - JOUR AU - Filardo, E. J. AU - Quinn, J. A. AU - Bland, K. I. AU - Frackelton, A. R. PY - 2000 DA - 2000// TI - Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF JO - Mol Endocrinol VL - 14 UR - https://doi.org/10.1210/mend.14.10.0532 DO - 10.1210/mend.14.10.0532 ID - Filardo2000 ER - TY - JOUR AU - Dowsett, M. PY - 2003 DA - 2003// TI - Preoperative models to evaluate endocrine strategies for breast cancer JO - Clin Cancer Res VL - 9 ID - Dowsett2003 ER - TY - JOUR AU - Chi, A. AU - Chen, X. AU - Chirala, M. AU - Younes, M. PY - 2003 DA - 2003// TI - Differential expression of estrogen receptor beta isoforms in human breast cancer tissue JO - Anticancer Res VL - 23 ID - Chi2003 ER - TY - JOUR AU - Cammarata, P. R. AU - Chu, S. AU - Moor, A. AU - Wang, Z. AU - Yang, S. H. AU - Simpkins, J. W. PY - 2004 DA - 2004// TI - Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells JO - Exp Eye Res VL - 78 UR - https://doi.org/10.1016/j.exer.2003.09.027 DO - 10.1016/j.exer.2003.09.027 ID - Cammarata2004 ER - TY - JOUR AU - Hengartner, M. O. PY - 2000 DA - 2000// TI - The biochemistry of apoptosis JO - Nature VL - 407 UR - https://doi.org/10.1038/35037710 DO - 10.1038/35037710 ID - Hengartner2000 ER - TY - JOUR AU - Finlay, D. AU - Vuori, K. PY - 2007 DA - 2007// TI - Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-1906 DO - 10.1158/0008-5472.CAN-07-1906 ID - Finlay2007 ER - TY - JOUR AU - Yao, Z. AU - Duan, S. AU - Hou, D. AU - Heese, K. AU - Wu, M. PY - 2007 DA - 2007// TI - Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism JO - Embo J VL - 26 UR - https://doi.org/10.1038/sj.emboj.7601571 DO - 10.1038/sj.emboj.7601571 ID - Yao2007 ER - TY - JOUR AU - Morishima, N. AU - Nakanishi, K. AU - Takenouchi, H. AU - Shibata, T. AU - Yasuhiko, Y. PY - 2002 DA - 2002// TI - An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12 JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M204973200 DO - 10.1074/jbc.M204973200 ID - Morishima2002 ER - TY - CHAP AU - Draper, M. W. AU - Flowers, D. E. AU - Huster, W. J. AU - Neild, J. A. AU - Harper, K. D. AU - Arnaud, C. PY - 1996 DA - 1996// TI - A controlled trial of raloxifene (LY139411681) HCl: impact on bone turnover and serum lipid profile in healthy postmenopausal women BT - J Bone Miner Res ID - Draper1996 ER - TY - JOUR AU - Boss, S. M. AU - Huster, W. J. AU - Neild, J. A. AU - Glant, M. D. AU - Eisenhut, C. C. AU - Draper, M. W. PY - 1997 DA - 1997// TI - Effects of raloxifene hydrochloride on the endometrium of postmenopausal women JO - Am J Obstet Gynecol VL - 177 UR - https://doi.org/10.1016/S0002-9378(97)70091-7 DO - 10.1016/S0002-9378(97)70091-7 ID - Boss1997 ER - TY - JOUR AU - Flamini, M. I. AU - Fu, X. D. AU - Sanchez, A. M. AU - Giretti, M. S. AU - Garibaldi, S. AU - Goglia, L. AU - Pisaneschi, S. AU - Tosi, V. AU - Genazzani, A. R. AU - Simoncini, T. PY - 2009 DA - 2009// TI - Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton JO - J Cell Mol Med VL - 13 UR - https://doi.org/10.1111/j.1582-4934.2008.00505.x DO - 10.1111/j.1582-4934.2008.00505.x ID - Flamini2009 ER - TY - JOUR AU - Esposito, E. AU - Iacono, A. AU - Raso, G. M. AU - Pacilio, M. AU - Coppola, A. AU - Di Carlo, R. AU - Meli, R. PY - 2005 DA - 2005// TI - Raloxifene, a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats JO - Endocrinology VL - 146 UR - https://doi.org/10.1210/en.2005-0375 DO - 10.1210/en.2005-0375 ID - Esposito2005 ER - TY - JOUR AU - Folkman, J. PY - 2001 DA - 2001// TI - Angiogenesis-dependent diseases JO - Semin Oncol VL - 28 UR - https://doi.org/10.1016/S0093-7754(01)90021-1 DO - 10.1016/S0093-7754(01)90021-1 ID - Folkman2001 ER - TY - JOUR AU - Doshida, M. AU - Ohmichi, M. AU - Tsutsumi, S. AU - Kawagoe, J. AU - Takahashi, T. AU - Du, B. AU - Mori-Abe, A. AU - Ohta, T. AU - Saitoh-Sekiguchi, M. AU - Takahashi, K. PY - 2006 DA - 2006// TI - Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M513251200 DO - 10.1074/jbc.M513251200 ID - Doshida2006 ER - TY - JOUR AU - Greenblatt, M. S. AU - Bennett, W. P. AU - Hollstein, M. AU - Harris, C. C. PY - 1994 DA - 1994// TI - Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis JO - Cancer Res VL - 54 ID - Greenblatt1994 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/10/566/prepub UR - http://www.biomedcentral.com/1471-2407/10/566/prepub ID - ref45 ER -