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Table 2 Novel RASSF1C target genes in T47D breast cancer cells

From: Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

Gene Gene discription Fold change
EFEM1 EGF-containing fibulin-like extracellular matrix protein 1 5.76
GHR growth hormone receptor 4.3
EGR1 early growth response 1 5.9
TP53IN1 tumor protein p53 inducible nuclear protein 1 4.46
MRAS muscle RAS oncogene homolog 3.8
MTUS1 mitochondrial tumor suppressor 1 -2
PROS protein S (alpha) 4
EMP1 epithelial membrane protein 1 -7.5
HOXA1 homeobox A1 4.6
SEPP1 selenoprotein P, plasma, 1 7.92
MGMT O-6-methylguanine-DNA methyltransferase 2.1
PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) 2.1
CXCR4 chemokine (C-X-C motif) receptor 4 3.6
CREG cellular repressor of E1A-stimulated genes 1 11.2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2
Noggin Noggin -3.6
SSP1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) -14.5
TGM2 TGM2: transglutaminase 2 (protein-glutamine-gamma-glutamyltransferase) 3
SRPX sushi-repeat-containing protein, X-linked -7.25
SAMD5 sterile alpha motif domain containing 5 -11.47
MAP1B microtubule-associated protein 1B -11.7
RNF182 ring finger protein 182 -13.8
TMEM8 transmembrane protein 158 -11.29
LDB2 LIM domain binding 2 -5.85
IGFBP3 insulin-like growth factor binding protein 3 -4.96
COL131 collagen, type XIII, alpha 1 -8.69
FRMDB FERM domain containing 4B -5.2
SOX9 SRY (sex determining region Y)-box 9 -4.5
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) -2.55
APOE apolipoprotein E 3.74
CCND2 cyclin D2 -3
SPANX1 sperm protein associated with the nucleus, X-linked, family member A1 7.38
SPANX1 SPANX family, member B1 17.7
HLADP1 major histocompatibility complex, class II, DP alpha 1 12.7
HIST1H2BC histone cluster 1 H2BC 5.34
DACH1 dachshund homolog 1 (Drosophila) 7.63
PCDH7 protocadherin 7 8.58
MYL9 myosin, light chain 9, regulatory 9
DPEP3 dipeptidase 3 10.66
CPE carboxypeptidase E 11.47
LITAF lipopolysaccharide-induced TNF facto 8.17
ABAT 4-aminobutyrate aminotransferase 10.82
  1. List of novel RASSF1C target genes identified in T47D breast cancer cells using microarray analysis. Affymetrix-microarray analysis was performed using T47D cells over-expressing RASSF1C as outlined in Materials and Methods section. Data analysis was performed using the dChip program [21] and the thresholds for selecting significant genes were set at a relative difference > = 1.5-fold (or/and 2-fold), absolute signal difference > = 50, and p < 0.05. Genes that met all three criteria were considered as significant changes. Comparison results with False Discovery Rate (FDR) <5% was considered as a valid analysis.