Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

BMC Cancer

Table 3 Deletion mutations found in canine GISTs in this study

Case	Codon	DNA Mutation	Amino Acid
2	556-557	GTA CAG TGG AAG GTT GTT → GTA C_AG GTT GTT	VQWKVV → VQVV
16	556-557	GTA CAG TGG AAG GTT GTT → GTA C_AG GTT GTT	VQWKVV → VQVV
1	556-558	GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT	VQWKVV → VQFV
5	556-558	GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT	VQWKVV → VQFV
12	556-558	GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT	VQWKVV → VQFV
15	556-558	GTA CAG TGG AAG GTT GTT → GTA CAG T TT GTT	VQWKVV → VQFV

The codon numbering is based upon the canine KIT amino acid sequence. The genomic DNA mutations were experimentally determined by direct sequencing and the altered sequence is underlined in column three. The expected amino acid changes in the protein are provided in column four. [GenBank: NC_006595.2, GenBank: NP_001003181].

ISSN: 1471-2407