Figure 4
Chemical structures of SMO substrates and inhibitors. Chemical structures of Spm, the specific substrate of SMO enzyme, of MDL 72527 (N1, N4-bis(2,3-butadienyl)-1,4butanediamine), an inhibitor of SMO, and of Spm-derivative analogues BENSpm (N1, N11-di(ethyl)norspermine) and CPENSpm (N1-cyclopropyl-methyl-N11-ethyl-norspermine). Abbreviations used in the figure are defined in the text.