Figure 6
From: Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells
Claudin-1 knockdown has little effects on apoptosis in T47 D cells. (A) T47 D cells were treated with control siRNA or siRNA against claudin-1 and treated as above. Cell lysates were subjected to Western blot analyses for claudin-1, cleaved PARP, E-cadherin, and actin. One representative of at least three independent experiments with similar results is shown. (B) The intensity of the bands for claudin-1, cleaved PARP and E-cadherin in control siRNA and claudin-1 siRNA - treated cells with or without tamoxifen (40 μM) for 20 h were quantified.