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Table 3 Comparison of WT vs KO mice Quantitative real-time pcr array: mouse stress response pathway

From: Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

Rank Well Gene Name Fold Change
1 A10 Casp3 caspase 3, apoptosis related cysteine protease -2.69
2 H02 Cdh1 cadherin 1 2.91
3 H12 Txnrd2 thioredoxin reductase 2, mitochondrial 3.53
4 A03 Mmp9 matrix metallopeptidase 9 -6.83
5 F03 Gpx3 glutathione peroxidase 3 13.2
6 C03 Hspb2 heat shock protein 2 1.66
7 G03 Gpx7 glutathione peroxidase 7 3.09
8 D06 Mmp2 matrix metallopeptidase 2 1.65
9 A12 Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 -1.73
10 D05 Aprt adenine phosphoribosyl transferase -1.86
11 B06 Bcl2l1 BCL2-like 1 -1.59
12 F10 Myc myelocytomatosis oncogene -1.60
13 F06 Sod1 superoxide dismutase 1, soluble -1.74
14 E12 Rad9 RAD9 homolog (S. pombe) -1.86
15 C04 Trp53 transformation related protein 53 -1.82
16 H08 Xpa xeroderma pigmentosum, complementation grp A 1.49
17 F07 Aoc3 amine oxidase, copper containing 3 2.13
18 H10 Pklr pyruvate kinase liver and red blood cell 1.96
  1. Global Pattern Recongition TM (GPR) Results for Mouse Stress Response 96 StellARray™. Four WT mammary carcinomas (125T3, 135T1, 191T3, and 139T6) were compared to four KO mammary carcinomas (183T1, 165T1, 155T1, and 172T1). The selection of mammary carcinomas for the real-time pcr experiment was based on the date of necropsy so that the mice would be fairly well age-matched. The average days on the study for the WT compared to Nrf2 KO mice were 166 vs. 170, respectively. Also, these tumors were strictly mammary adenocarcinomas, not mixed with lymphoma or adenoacanthoma. P-values ranged from 0.11 - 0.24, and so these results are considered "leads" not statistically significant.