Figure 3

ERBB2- amplicon size is significantly different in ERBB2 -amplified IBC and NIBC. Unsupervised hierarchical clustering of genome copy number profiles measured for 54 ERBB2-amplified primary breast tumors by aCGH on 650 17q12-q21 probes within the genomic interval defined from centromere to telomere by [AATF-STAT3] (bar to the left) (Additionnal file 1-Table S5). Below the dendrogram, name of tumors are given and the row indicates their ER (black square, ER+; white square, ER-) and IBC/NIBC (orange and blue boxes, respectively) status, respectively. Corresponding legends are indicated in the box located to the top right. On the right, the scores obtained for all BCs, IBCs and NIBCs are plotted (red, orange and blue lines, respectively) as a function of chromosome location. ERBB2-amplicon size varies within a region delimited by DDX52 and KRT40 genes. IBCs have a smaller amplicon than NIBCs located within a region delimited by PLXDC1 and KRT40 genes.