Figure 1

aCGH profiling of ERBB2 -amplifed BCs. Unsupervised hierarchical clustering of genome copy number profiles measured for 54 ERBB2-amplified primary breast tumors by aCGH on 225,388 probes (without X and Y). Red indicates increased genome copy number and green indicates decreased genome copy number. The bars to the left indicate chromosome locations with chromosome 1pter to the top and 22qter to the bottom. The location of the odd-numbered chromosomes is indicated at left. The vertical orange dotted line defines the limits of the two major sample clusters defined by their respective AU (approximately unbiased) p-values Below the dendrogram, name of tumors are given and the rows indicate their ER and PR IHC status (black square, ER+ or PR+; white square, ER- or PR-). CNA frequencies discriminate ER+ and ER- ERBB2-amplified breast tumors (see also Additionnal file 1-Table S3). On the right, frequencies of CNA (gains and losses) are plotted as a function of chromosome location. Horizontal lines indicate chromosome boundaries. Positive and negative values indicate frequencies of tumors showing copy number increase and decrease, respectively, with gains and losses as described in the method section.