Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?

BMC Cancer

Table 2 Clinical and demographic differences of polyps with and without MUC immunoreactivity

	MUC1 Staining		MUC2 Staining		MUC5AC Staining		MUC6 Staining
	+	-	+	-	+	-	+	-
Age
Mean	59.86	59.45	59.55	59.00	59.37	59.67	61.14	59.10
	P = 0.803		P = 0.933		P = 0.837		P = 0.231
Gender
Male	72	198	266	4	112	158	61	209
Female	33	150	182	1	83	100	39	144
	P = 0.020		P = 0.462		P = 0.491		P = 0.824
Site
Right colon	37	119	154	2	73	83	27	127
Left colon	54	172	224	2	94	132	57	169
Rectum	15	56	70	1	27	44	14	57
	P = 0.908		P = 0.975		P = 0.370		0.404
Configuration
Hyperplastic	0	36	36	0	13	23	0	36
Serrated	4	11	13	2	10	5	4	11
TA¹	69	189	258	0	117	141	57	201
TVA¹	21	93	113	1	43	71	28	86
VA¹	12	19	29	2	12	19	11	20
	P = 0.001		P < 0.0001		P = 0.182		P = 0.007
Type
Hyperplastic	0	36	36	0	13	23	0	36
Serrated	4	11	13	2	10	5	4	11
Mixed adenomatous-hyperplastic	0	17	17	0	3	14	3	14
Low-grade adenomatous	70	239	309	0	136	173	74	235
High-grade adenomatous	32	45	74	3	33	44	19	58
	p < 0.0001		p < 0.0001		P = 0.069		P = 0.021
Invasion² % within MUC+/-	9.4%	4%	4.7%	60%	3.6%	6.6%	13%	3.1%
	P = 0.029		p < 0.0001		P = 0.161		p < 0.0001

¹ Abbreviations: TA, tubular adenoma; TVA, tubulovillous adenoma; VA, villous adenomas; ² Invasion not beyond mucosa or muscularis mucosae

ISSN: 1471-2407