Application of tumor-node-metastasis staging 2002 version in locally advanced hepatocellular carcinoma: is it predictive of surgical outcome?

Li, Binkui; Yuan, Yunfei; Chen, Guihua; He, Liru; Zhang, Yaqi; Li, Jinqing; Li, Guohui; Lau, Wan Yee

doi:10.1186/1471-2407-10-535

Table 2 Univariate analysis of prognostic factors by log-rank test

From: Application of tumor-node-metastasis staging 2002 version in locally advanced hepatocellular carcinoma: is it predictive of surgical outcome?

Variable	Cases	1y-OS(%)	3y-OS(%)	5y-OS(%)	P
Gender					0.913
Female	22	45.5	31.8	18.2
Male	276	59.1	25.9	15.9
Age (years)					0.079
≤48	146	54.7	22.9	13.7
>48	152	60.5	29.6	18.3
HBsAg					0.269
Negative	41	58.7	37.6	18.8
Positive	257	56.5	23.2	14.9
HCVAb					0.380
Negative	280	55.2	27.3	18.2
Positive	18	47.5	22.0	12.9
ALB (g/L)					0.004
≤35	37	42.3	7.7	0.0
>35	261	59.6	27.7	17.3
TBIL (μmol/L)					0.879
≤20	204	62.8	29.3	16.0
>20	94	58.0	28.0	14.3
PT (s)					0.185
≤13.5	148	62.0	32.9	22.3
>13.5	150	57.0	24.6	14.4
ICGR15 (%)					0.423
≤10	155	52.2	26.7	17.8
>10	143	61.7	28.2	19.4
AFP (μg/L)					0.112
≤25	48	63.2	34.3	20.5
>25	250	56.0	25.8	16.0
Child-Pugh					0.275
A	260	59.4	27.4	16.5
B	38	50.0	18.8	12.5
MELD					0.243
≤7	169	58.0	24.7	13.9
>7	129	57.2	32.6	20.7
Cirrhosis					0.028
No	57	61.0	39.5	26.6
Yes	241	57.8	23.5	13.8
Tumor size(cm)					0.278
≤5	35	66.0	31.0	21.0
>5	263	56.0	23.5	14.5
Variable	Cases	1y-OS(%)	3y-OS(%)	5y-OS(%)	P
Tumor number					0.101
Solitary	108	59.7	33.3	23.3
Multiple	190	57.8	23.1	12.5
Tumor location					0.126
Unilobar	255	52.7	27.2	17.3
Bilobar	43	45.2	21.4	10.0
Tumor encapsulation					0.093
Yes	87	54.1	26.1	18.1
No	211	44.1	17.0	12.0
Microvascular invasion					0.117
No	111	56.5	24.0	16.7
Yes	187	48.1	19.4	11.0
Major vascular invasion					<0.001
No	237	65.2	32.2	19.6
Yes	61	29.7	0.0	0.0
Invasion of adjacent organs					0.197
No	219	59.9	27.7	16.0
Yes	69	56.3	17.0	12.4
Perforation of visceral peritoneum					0.295
No	220	60.1	26.9	18.4
Yes	78	53.8	21.0	13.6
Resection margin(mm)					0.201
0	188	49.3	20.8	12.7
>0	110	58.4	26.1	17.9
Resection extent					0.062
Major	217	54.7	23.5	15.2
Minor	81	67.9	28.0	18.9
Blood loss(L)					0.140
≤0.8	163	62.8	30.5	21.5
>0.8	135	52.9	21.2	12.9
Blood transfusion					0.488
No	142	59.0	26.3	17.6
Yes	157	57.9	26.6	14.4
Previous TACE					0.724
No	282	57.3	27.1	16.4
Yes	16	48.4	21.3	13.2
Postoperative adjuvant TACE					0.923
No	222	61.7	28.6	15.5
Yes	76	53.2	23.0	15.2

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