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Table 5 13 tumors for which interobserver disagreement arose regarding the results of immunohistochemistry.

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Code No. Immunohistochemistry FISH
-- CNB Surgery Interpretation CNB Surgery
84 0 (0/0/0) 2+(2/1/2) Processing, hetero Neg Neg
23 1+(1/1/1) 2+(2/1/2) Heterogeneity Neg Neg
24 1+(2/1/1) 2+(2/2/2) Heterogeneity Neg NA
67 1+(1/0/1) 2+(2/1/2) Processing, border Neg Pos
10 2+(2/2/2) 1+(1/1/1) Processing Neg Neg
43 2+(2/1/2) 0 (0/0/0) Processing Neg Neg
69 2+(2/1/2) 1+(1/1/1) Processing, border Neg Neg
52 2+(3/2/2) 3+(3/3/2) Processing, border Pos Pos
90 2+(3/2/2) 3+(3/3/3) Processing, border Pos Pos
92 2+(2/2/2) 3+(3/3/3) Predominantly DCIS Pos Pos
94 2+(2/2/2) 3+(3/3/2) Processing, border Pos Pos
102 2+(3/2/2) 3+(3/3/3) Processing, border Pos Pos
54 3+(3/3/3) 0 (0/2/0) Heterogeneity Neg Neg
  1. FISH, fluorescence in situ hybridization; NA, Data were not available; neg, negative; pos, positive; parenthesis, judgments of scores by three observers (Underlines indicate interobserver disagreement.)