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Table 4 Concordance of consensus HER2 judgments by immunohistochemistry between core needle biopsy and corresponding surgically resected specimens.

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

3 categories (0 or 1+ vs. 2+ vs. 3+)
HER2 score for surgically resected specimens Number of tumors
  HER2 score for CNB specimens
  0 or 1+ 2+ 3+
0 or 1+ 56 3 1
2+ 4 11 0
3+ 0 5 20
% agreement = 87%, κ = 0.77, standard deviation (σ) = 0.045
2 categories (0, 1+. or 2+ vs. 3+)
HER2 score for surgically resected specimens Number of tumors
  HER2 score for CNB specimens
  0, 1+ or 2+   3+
0, 1+, or 2+ 74   1
3+ 5   20
% agreement = 94%, κ = 0.83, σ = 0.038    
  1. The judgments were performed according to the 2007 ASCO/CAP guideline.