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Table 2 Surgically resected tumor specimens for which interobserver disagreement arose regarding the results of HER2 immunohistochemistry.

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Code Final score IHC score FISH (HER2/CEP17)
   Observer A Observer B Observer C  
S54 0+ 0 2+ 0 - (0.92)
S17 1+ 1+ 1+ 2+ NA
S26 1+ 1+ 1+ 2+ - (0.68)
S78 1+ 1+ 1+ 2+ - (0.82)
S79 1+ 2+ 1+ 1+ - (0.89)
S76 1+ 2+ 1+ 1+ - (0.95)
S82 1+ 2+ 1+ 1+ - (0.97)
S77 1+ 2+ 1+ 1+ - (1.47)
S23 2+ 2+ 1+ 2+ - (0.47)
S22 2+ 2+ 1+ 2+ - (0.92)
S16 2+ 3+ 2+ 2+ - (1.03)
S84 2+ 2+ 1+ 2+ - (1.13)
S67 2+ 2+ 1+ 2+ + (2.24)
S97 2+ 3+ 2+ 2+ + (3.89)
S103 2+ 3+ 2+ 2+ + (7.75)
S91 2+ 3+ 2+ 2+ + (7.77)
S94 3+ 3+ 3+ 2+ + (3.61)
S52 3+ 3+ 3+ 2+ + (5.09)
S42 3+ 3+ 3+ 2+ + (9.24)
S18 3+ 3+ 3+ 2+ + (12.40)
  1. The HER2 score was assigned according to the 2007 ASCO/CAP guideline [10]. The majority score was assigned as the final score for the tumor. NA, not available because FISH was not successful.
  2. FISH, fluorescence in situ hybridization; IHC, immunohistochemistry