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Table 2 Surgically resected tumor specimens for which interobserver disagreement arose regarding the results of HER2 immunohistochemistry.

From: HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

Code

Final score

IHC score

FISH (HER2/CEP17)

  

Observer A

Observer B

Observer C

 

S54

0+

0

2+

0

- (0.92)

S17

1+

1+

1+

2+

NA

S26

1+

1+

1+

2+

- (0.68)

S78

1+

1+

1+

2+

- (0.82)

S79

1+

2+

1+

1+

- (0.89)

S76

1+

2+

1+

1+

- (0.95)

S82

1+

2+

1+

1+

- (0.97)

S77

1+

2+

1+

1+

- (1.47)

S23

2+

2+

1+

2+

- (0.47)

S22

2+

2+

1+

2+

- (0.92)

S16

2+

3+

2+

2+

- (1.03)

S84

2+

2+

1+

2+

- (1.13)

S67

2+

2+

1+

2+

+ (2.24)

S97

2+

3+

2+

2+

+ (3.89)

S103

2+

3+

2+

2+

+ (7.75)

S91

2+

3+

2+

2+

+ (7.77)

S94

3+

3+

3+

2+

+ (3.61)

S52

3+

3+

3+

2+

+ (5.09)

S42

3+

3+

3+

2+

+ (9.24)

S18

3+

3+

3+

2+

+ (12.40)

  1. The HER2 score was assigned according to the 2007 ASCO/CAP guideline [10]. The majority score was assigned as the final score for the tumor. NA, not available because FISH was not successful.
  2. FISH, fluorescence in situ hybridization; IHC, immunohistochemistry