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Table 4 Sensitivity, specificity, positive and negative predictive values and likelihood ratios of the various methods

From: Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

  No. positive Sens
≥ CIN2
Spec
≥ CIN2
PPV
≥ CIN 2
NPV
≥ CIN 2
PLR
≥ CIN 2
NLR
≥ CIN2
ThinPrep Pap
≥ ASCUS
241/1270 18.9% 26/26
100%
1029/1244
82.7%
26/241
10.8%
1029/1029
100%
5.8 0
ThinPrep Pap
≥ LSIL
140/1270
11%
23/26
88.5%
1127/1244
90.6%
23/140
16.4%
1127/1130
99.7%
9.4 0.13
ThinPrep Pap
≥ HSIL
21/1270
1.7%
21/26
80.8%
1244/1244
100%
21/21
100%
1244/1249 99.6% 0.19
HC2 (+) ALL 260/1270 20.4% 19/26
73.1%
1003/1244
80.6%
19/260
7.3%
1003/1010
99.3%
3.8 0.21
HC2 (+)
HR only
185/1270
14.6%
19/26
73.1%
1078/1244
86.7%
19/185
10.3%
1078/1085
99.4%
5.5 0.31
HPV PCR (+) 397/1270
31.3%
26/26
100%
873/1244
70.2%
26/397
6.5%
873/873
100%
3.4 0
HPV PCR (+)
16/18/31/33
109/1270
8.6%
21/26
80.8%
1156/1244
92.9%
21/109
19.3%
1156/1161
99.6%
11.4 0.21
  No. positive Sens
≥ CIN3
Spec
≥ CIN 3
PPV
≥ CIN 3
NPV
≥ CIN 3
PLR
≥ CIN 3
NLR
≥ CIN 3
ThinPrep Pap
≥ ASCUS
241/1270 18.9% 15/15
100%
1029/1255
82%
15/241
6.2%
1029/1029
100%
5.6 0
ThinPrep Pap
≥ LSIL
140/1270
11%
14/15
93.3%
1129/1255
90%
14/140
10%
1129/1130
99.9%
9.3 0.07
ThinPrep Pap
≥ HSIL
21/1270
1.7%
14/15
93.3%
1248/1255
99.44
14/21
66.7
1248/1249
99.9%
166.6 0.067
HC2 (+) ALL 260/1270 20.4% 11/15
73.3%
1006/1255
80.2%
11/260
4.2%
1006/1010
99.6%
3.7 0.33
HC2 (+)
HR only
185/1270
14.6%
11/15
73.3%
1081/1255
86.1%
11/185
5.9%
1081/1085
99.6%
5.3 0.31
HPV PCR (+) 397/1270
31.3%
15/15
100%
873/1255
69.6%
15/397
3.8%
873/873
100%
3.2 0
HPV PCR (+)
16/18/31/33
109/1270
8.6%
15/15
100%
1161/1255
92.5%
15/109
13.8%
1161/1161
100%
13.4 0
  1. HSIL: High-grade squamous intraepithelial lesion, Sens: sensitivity, Spec: specificity, PPV: Positive predictive value, NPV: Negative predictive value, PLR: positive likelihood ratio, NLR: negative likelihood ratio