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Table 4 Sensitivity, specificity, positive and negative predictive values and likelihood ratios of the various methods

From: Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

 

No. positive

Sens

≥ CIN2

Spec

≥ CIN2

PPV

≥ CIN 2

NPV

≥ CIN 2

PLR

≥ CIN 2

NLR

≥ CIN2

ThinPrep Pap

≥ ASCUS

241/1270 18.9%

26/26

100%

1029/1244

82.7%

26/241

10.8%

1029/1029

100%

5.8

0

ThinPrep Pap

≥ LSIL

140/1270

11%

23/26

88.5%

1127/1244

90.6%

23/140

16.4%

1127/1130

99.7%

9.4

0.13

ThinPrep Pap

≥ HSIL

21/1270

1.7%

21/26

80.8%

1244/1244

100%

21/21

100%

1244/1249 99.6%

∞

0.19

HC2 (+) ALL

260/1270 20.4%

19/26

73.1%

1003/1244

80.6%

19/260

7.3%

1003/1010

99.3%

3.8

0.21

HC2 (+)

HR only

185/1270

14.6%

19/26

73.1%

1078/1244

86.7%

19/185

10.3%

1078/1085

99.4%

5.5

0.31

HPV PCR (+)

397/1270

31.3%

26/26

100%

873/1244

70.2%

26/397

6.5%

873/873

100%

3.4

0

HPV PCR (+)

16/18/31/33

109/1270

8.6%

21/26

80.8%

1156/1244

92.9%

21/109

19.3%

1156/1161

99.6%

11.4

0.21

 

No. positive

Sens

≥ CIN3

Spec

≥ CIN 3

PPV

≥ CIN 3

NPV

≥ CIN 3

PLR

≥ CIN 3

NLR

≥ CIN 3

ThinPrep Pap

≥ ASCUS

241/1270 18.9%

15/15

100%

1029/1255

82%

15/241

6.2%

1029/1029

100%

5.6

0

ThinPrep Pap

≥ LSIL

140/1270

11%

14/15

93.3%

1129/1255

90%

14/140

10%

1129/1130

99.9%

9.3

0.07

ThinPrep Pap

≥ HSIL

21/1270

1.7%

14/15

93.3%

1248/1255

99.44

14/21

66.7

1248/1249

99.9%

166.6

0.067

HC2 (+) ALL

260/1270 20.4%

11/15

73.3%

1006/1255

80.2%

11/260

4.2%

1006/1010

99.6%

3.7

0.33

HC2 (+)

HR only

185/1270

14.6%

11/15

73.3%

1081/1255

86.1%

11/185

5.9%

1081/1085

99.6%

5.3

0.31

HPV PCR (+)

397/1270

31.3%

15/15

100%

873/1255

69.6%

15/397

3.8%

873/873

100%

3.2

0

HPV PCR (+)

16/18/31/33

109/1270

8.6%

15/15

100%

1161/1255

92.5%

15/109

13.8%

1161/1161

100%

13.4

0

  1. HSIL: High-grade squamous intraepithelial lesion, Sens: sensitivity, Spec: specificity, PPV: Positive predictive value, NPV: Negative predictive value, PLR: positive likelihood ratio, NLR: negative likelihood ratio