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Table 2 ThinPrep diagnosis in relation to HPV DNA detection by HC2 or PCR

From: Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

HC2

WNL

ASCUS

LSIL

HSIL

SCC

AdenoCa

Total

HC2 +

105

45

93

8

9

0

260

Negative

924

56

26

2

1

1

1010

Total

1029

101

119

10

10

1

1270

PCR

WNL

ASCUS

LSIL

HSIL

SCC

AdenoCa

Total

HPV X

159

38

30

0

0

0

227

HPV 6

10

4

9

1

0

0

24

HPV 11

0

13

13

1

0

0

27

HPV 16

0

3

§

0

10

HPV 18

0

5

§

1

15

HPV 31

1

2

§

§

0

4

HPV 33

10

§

§

§

§

0

10

Multiple HPV types§

5

20

43§

0

80

PCR +

185

86

105

10

10

1

397

Negative

844

15

14

0

0

0

873

Total

1029

101

119

10

10

1

1270

  1. Abbreviations: HC2: Hybrid Capture 2; HPV: Human Papillomavirus; WNL: Within Normal Limits; Hyperk: Hyperkeratosis; ASCUS: Atypical Squamous Cells of Undetermined Significance; LSIL: Low-grade Squamous Intraepithelial Lesion;
  2. HSIL: High-grade Squamous Intraepithelial Lesion; SCC: Squamous Cell Carcinoma; AdenoCa: Adenococarcinoma
  3. §Denotes the presence of mixed infections that are summarized under multiple HPV types. Nine HPV 16 mixed infections had LSIL, six had HSIL and four SCC. Twenty-seven HPV 18 mixed infections had LSIL, five had HSIL and three SCC. Nine HPV 31 mixed infections had LSIL, one had HSIL and two SCC. Seven HPV 33 mixed infections had LSIL, two had HSIL and three SCC.