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Table 2 ThinPrep diagnosis in relation to HPV DNA detection by HC2 or PCR

From: Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

HC2 WNL ASCUS LSIL HSIL SCC AdenoCa Total
HC2 + 105 45 93 8 9 0 260
Negative 924 56 26 2 1 1 1010
Total 1029 101 119 10 10 1 1270
PCR WNL ASCUS LSIL HSIL SCC AdenoCa Total
HPV X 159 38 30 0 0 0 227
HPV 6 10 4 9 1 0 0 24
HPV 11 0 13 13 1 0 0 27
HPV 16 0 3 § 0 10
HPV 18 0 5 § 1 15
HPV 31 1 2 § § 0 4
HPV 33 10 § § § § 0 10
Multiple HPV types§ 5 20 43§ 0 80
PCR + 185 86 105 10 10 1 397
Negative 844 15 14 0 0 0 873
Total 1029 101 119 10 10 1 1270
  1. Abbreviations: HC2: Hybrid Capture 2; HPV: Human Papillomavirus; WNL: Within Normal Limits; Hyperk: Hyperkeratosis; ASCUS: Atypical Squamous Cells of Undetermined Significance; LSIL: Low-grade Squamous Intraepithelial Lesion;
  2. HSIL: High-grade Squamous Intraepithelial Lesion; SCC: Squamous Cell Carcinoma; AdenoCa: Adenococarcinoma
  3. §Denotes the presence of mixed infections that are summarized under multiple HPV types. Nine HPV 16 mixed infections had LSIL, six had HSIL and four SCC. Twenty-seven HPV 18 mixed infections had LSIL, five had HSIL and three SCC. Nine HPV 31 mixed infections had LSIL, one had HSIL and two SCC. Seven HPV 33 mixed infections had LSIL, two had HSIL and three SCC.