Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

Table 2 ThinPrep diagnosis in relation to HPV DNA detection by HC2 or PCR

HC2	WNL	ASCUS	LSIL	HSIL	SCC	AdenoCa	Total
HC2 +	105	45	93	8	9	0	260
Negative	924	56	26	2	1	1	1010
Total	1029	101	119	10	10	1	1270
PCR	*WNL*	*ASCUS*	*LSIL*	*HSIL*	*SCC*	*AdenoCa*	Total
HPV X	159	38	30	0	0	0	227
HPV 6	10	4	9	1	0	0	24
HPV 11	0	13	13	1	0	0	27
HPV 16	0	2§	3	§	5§	0	10
HPV 18	0	8§	5	§	1§	1	15
HPV 31	1	1§	2	§	§	0	4
HPV 33	10	§	§	§	§	0	10
Multiple HPV types§	5	20	43§	8§	4§	0	80
PCR +	185	86	105	10	10	1	397
Negative	844	15	14	0	0	0	873
Total	1029	101	119	10	10	1	1270

Abbreviations: HC2: Hybrid Capture 2; HPV: Human Papillomavirus; WNL: Within Normal Limits; Hyperk: Hyperkeratosis; ASCUS: Atypical Squamous Cells of Undetermined Significance; LSIL: Low-grade Squamous Intraepithelial Lesion;
HSIL: High-grade Squamous Intraepithelial Lesion; SCC: Squamous Cell Carcinoma; AdenoCa: Adenococarcinoma
§Denotes the presence of mixed infections that are summarized under multiple HPV types. Nine HPV 16 mixed infections had LSIL, six had HSIL and four SCC. Twenty-seven HPV 18 mixed infections had LSIL, five had HSIL and three SCC. Nine HPV 31 mixed infections had LSIL, one had HSIL and two SCC. Seven HPV 33 mixed infections had LSIL, two had HSIL and three SCC.

ISSN: 1471-2407