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Table 4 Analysis of cancer specific survival (CSS) in RCC, patients with metastases

From: Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

 

Univariate Analysis

Multivariate Analysis

Variable

HR

95% CI

p

HR

95% CI

p

Grading 2 vs. 1

0.59

0.24-1.44

0.247

0.65

0.25-1.74

0.395

Grading 3/4 vs. 1

1.03

0.43-2.45

0.950

1.18

0.47-3.01

0.725

Karnofsky < 80 vs. ≥ 80

1.90

0.99-3.64

0.054

2.24

0.99-5.05

0.052

Age ≥ 65 years vs. < 65 years

1.39

0.84-2.31

0.202

1.47

0.79-2.73

0.228

Sex (Male vs. Female)

1.28

0.75-2.19

0.372

1.35

0.74-2.45

0.331

Clear cell RCC vs. non clear cell RCC

0.59

0.25-1.38

0.223

0.36

0.15-0.88

0.025

Nuclear EZH2 1-5% vs. 0%

2.18

0.95-5.00

0.065

2.63

1.03-6.71

0.043

Nuclear EZH2 >5-25% vs. 0%

2.92

1.22-6.97

0.016

3.35

1.29-8.74

0.013

Nuclear EZH2 >25-50% vs. 0%

3.91

1.51-10.16

0.005

4.92

1.72-14.10

0.003

Nuclear EZH2 >50% vs. 0%

0.98

0.25-3.91

0.978

0.70

0.13-3.75

0.677