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Table 1 Allele and genotype frequencies of 5 SNPs among colorectal cancer and schizophrenia patients

From: Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

SNP ID

genotype frequency(%)

pvalue*

FDR adjusted

allele frequency(%)

X2

pvalue*

FDR adjusted

Odds Ratio (95%CI)

rs6452526

CC

CT

TT

  

C

T

    

CRC

194(75.5)

57(22.2)

6(2.3)

0.021

0.105

455(86.6)

69(13.4)

8.276

0.004

0.020

0.61(0.44-0.86)

SZ

159(64.9)

73(29.8)

13(5.3)

  

391(79.8)

99(20.2)

    

rs2662238

AA

AG

GG

  

A

G

    

CRC

12(4.3)

77(27.4)

192(68.3)

0.895

0.895

101(18.0)

461(82.0)

0.222

0.637

0.637

0.93(0.68-1.26)

SZ

13(5.0)

74(28.2)

175(66.8)

  

100(19.1)

424(80.9)

    

rs963248

AA

AG

GG

  

A

G

    

CRC

29(10.9)

105(39.6)

131(49.4)

0.296

0.493

163(30.8)

367(69.2)

1.303

0.254

0.317

1.17(0.89-1.53)

SZ

18(7.0)

105(41.0)

133(52.0)

  

141(27.5)

371(72.5)

    

rs35268

CC

CT

TT

  

C

T

    

CRC

2(0.7)

47(16.8)

230(82.4)

0.078

0.194

51(9.1)

507(90.9)

4.834

0.028

0.070

1.54(1.05-2.26)

SZ

3(1.2)

62(24.4)

189(74.4)

  

68(13.4)

440(86.6)

    

rs2386275

AA

AG

GG

  

A

G

    

CRC

124(52.3)

86(36.3)

27(11.4)

0.416

0.520

334(70.5)

140(29.5)

1.583

0.208

0.347

1.20(0.91-1.58)

SZ

146(56.2)

93(35.8)

21(8.1)

  

385(74.0)

135(26.0)

    
  1. *Pearson's p value, SNP = single nucleotide polymorphism, FDR = false discovery rate, CI = confidence interval, CRC = colorectal cancer, SZ = schizophrenia.