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Table 2 CD44s expression in lymphoma: comparison of published data with this study

From: Epigenetic regulation of CD44in Hodgkin and non-Hodgkin lymphoma

 

published data

this study

Lymphoma subtype

CD44s protein [reference]

CD44unmethylated promoter in primary lymphomas

CD44unmethylated promoter in cell lines

CD44s expression in cell lines

HL

pos [45]

n.d.

3/7

5/7

ALCL

pos [46]

n.d.

2/5

3/5

BL

neg [48, 55]

11/29

0/7

0/7

FL

nodal FL

pos/neg [55]

neg [45]

n.d.

2/6

2/6

DLBCL

pos/neg [47, 55, 56]

9/10

2/8

2/8

MCL

pos [44]

11/11

6/7

7/7

normal lymphoid tissue

pos [40, 41]

3/3

  
  1. Comparison of CD44s protein expression in samples of lymphoma patients as reported in the literature and CD44 methylation status and CD44s gene expression in lymphoma cell lines and patient samples analyzed in our study. CD44 methylation status was determined by MSP (primary samples) or MS-MLPA (cell lines), CD44 gene expression levels were analyzed by qRT-PCR. pos = most of the reported samples were CD44 positive, neg = all analyzed samples were negative for CD44. pos/neg = CD44+ and CD44- samples were described, n.d. = not determined.