Figure 1

Methylation status and deletions of TSG in lymphoma cell lines. MS-MLPA results of 40 lymphoma cell lines show the methylation status and copy number of 24 TSG. As control, DNA samples from tonsils and PBMC of three healthy donors were analyzed. In each lymphoma subgroup cell lines are arranged alphabetically. TSG are sorted from left to right according to frequency of methylation and/or deletion. According to the incidences of methylated and/or deleted TSG in cell lines, TSG can be divided in 3 groups: group A (methylated and/or deleted in ≤ 10% of cell lines), group B (methylated and/or deleted in 10 to 89% of cell lines) and group C (methylated and/or deleted in ≥ 90%). yellow = TSG unmethylated and not deleted; green = TSG methylated and/or deleted; del = deleted; o. del = only deleted, not methylated.