Table 1 FLT3 mutations among 517 acute leukemia subjects from the Northern California Childhood Leukemia Study

0004

ITD

6.1

46, XY [10/20]; 46, XY, del(9)(p13) [9/20]; 47, XY, +?22 [1/20]

ALL

neg

0087

ITD

10.5

46, XY [21/24]

AML-M1

neg

0104

ITD

9.1

46, XY [19/20]; 44, XY, -14, -22 [1/20]

ALL-L1 (T-cell)

neg

0126

ITD

14.9

46, XX [20/20]

AML-M2

0201

MUT

GAT→GAA D835E

13.2

46, XY [20/20]

AML-M2

0261

ITD

13.7

46, XX, t(6;9)(p23;q34) [23/24]

AML-M2

neg

0544 ^‡

MUT

GAT→GTT D835V

5.3

46, XX [20/20]; nuc ish 12p13(TEL×2), 21q22(AML1×4) [149/207]/12p13(TEL×2), 21q22(AML×2) [31/207]/12p13(TEL×2), 21q22(AML1×3) [25/207]

ALL

neg

0678

ITD

14.5

46, XX [20]

AML-M2

0738

MUT

TAT→TGT Y842C

5.0

45, XY, -7, del(13)(q13q21) [12/20]; 46, XY [8/20]

ALL-L1

0745

MUT

GAT→TAT D835Y

12.7

46, XY [21/21]; nuc ish 4cen(CEP4×2),

10cen(CEP10×2), 12p13(TEL×2), 21q22(AML1×2)

ALL-L1/L2

0796 ^‡

MUT

GAT→TAT D835Y

1.8

46, XY [3/3]; nuc ish 12p13 (TEL×3), 21q22(AML1×4) [90/100], 12p13(TEL×2), 21q22(AML1×2) [10/100] FISH: +12++21/++X (presumed cryptic high hyperdiploidy)

ALL-L1

neg

0803

MUT

GAT→TAT D835Y and GAT→CAT D835H

0.3

46, XY [20/20]; nuc ish 11q23 (MLL5'x2, MLL3'x2) [200/200]

AML-M5

0945 ^‡

MUT

GAT→TAT D835Y

7.9

46, XY [21/21]

ALL

neg

0999

ITD

8.3

46, XX [20]

AML

1043

MUT

GAT→CAT D835H

14.0

46, XY, inv(16)(p12q22) [12/12]

AML

1073 ^‡

DEL

5.9

46, XY [30]; nuc ish 9q34(ABL×2), 22q11.2(BCR×2)

ALL

neg

1107 ^‡§

MUT

GAT→GCT D835A

3.5

56~58, XY, dup(1)(q21q32),+4,+5,+6,+10,+14,+18,+18,+19,+21, +22,+2mar [5/23]; 46, XY [18/23]

ALL-L1

1148

ITD

14.5

47, XX, +14 [16]

AML

neg