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Table 2 Immunostaining of HAS1, HAS2 and HAS3 in human endometrium and its lesions

From: Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

   HAS1
staining
intensity*
   HAS2
staining
intensity*
   HAS3
staining
intensity*
  
   Epithelium   Stroma Epithelium   Stroma Epithelium   Stroma  
   n.d. weak moderate n.d. weak n.d. weak moderate n.d. weak n.d. weak moderate n.d. weak
Normal n = 10   4 2 (10-25%) 4 (10-50%) 7 3 (5-50%) 7 3 (5-10%) 0 8 2 (25%) 5 5 (10-20%) 0 9 1(10%)
Proliferating pm n = 5 5 0 0 5 0 5 0 0 1 4 (5%) 5 0 0 5 0
Hyperplasia # n = 4 1 3 (5-25%) 0 3 1 (10%) 1 2 (10-25%) 1 (50%) 3 1 (10%) 2 2 (10%) 0 3 1(25%)
Grade 1 n = 8 0 5 (5-50%) 3 (25-50%) 6 2 (5%) 2 5 (5-25) 1 (50%) 8 0 3 3 (5-25%) 2 (25-50%) 8 0
Grade 2 + 3 n = 8 0 2 (25-50%) 6 (5-50%) 8 0 0 5 (5-50%) 3 (5-50) 7 1 (5%) 0 3 (10-20%) 5 (10-25%) 8 0
  1. * num. of samples with % of positive cells (% in median; range when necessary)
  2. n.d. = not detected/negative
  3. # complex atypical hyperplasia
  4. pm = post-menopausal
  5. ‡ endometrioid endometrial adenocarcinoma
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