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Table 3 PFS and OS according to CYP1B1 polymorphisms

From: Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients

  Median PFS Median OS
Genotype Mos 95% CI P Mos 95% CI P
CYP1B1 4326CG       
   CC + GC 8.3 7.7-8.8 0.032 28.3 17.3-39.2 < 0.001
   GG 4.8 2.0-7.6   15.8 5.3-26.3  
CYP1B1 4390AG       
   AA 7.5 6.1-8.9 0.295 19.8 15.6-24.0 0.945
   AG+ GG 7.0 2.6-11.3   10.4 11.3-29.5  
CYP1B1 412CG       
   CC + CG 7.1 5.3-8.8 0.656 18.9 15.8-22.0 0.584
   GG 7.5 5.9-9.1   21.2 13.2-29.1  
  1. Abbreviations: Mos, months; NR, not reached OS, overall survival; PFS, progression-free-survival. P values were calculated with log-rank test.
  2. Note. The event-rate was 51.7%, and 6 patients were alive without progression at the last follow-up (July 2008).