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Table 3 PFS and OS according to CYP1B1 polymorphisms

From: Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients

 

Median PFS

Median OS

Genotype

Mos

95% CI

P

Mos

95% CI

P

CYP1B1 4326CG

      

   CC + GC

8.3

7.7-8.8

0.032

28.3

17.3-39.2

< 0.001

   GG

4.8

2.0-7.6

 

15.8

5.3-26.3

 

CYP1B1 4390AG

      

   AA

7.5

6.1-8.9

0.295

19.8

15.6-24.0

0.945

   AG+ GG

7.0

2.6-11.3

 

10.4

11.3-29.5

 

CYP1B1 412CG

      

   CC + CG

7.1

5.3-8.8

0.656

18.9

15.8-22.0

0.584

   GG

7.5

5.9-9.1

 

21.2

13.2-29.1

 
  1. Abbreviations: Mos, months; NR, not reached OS, overall survival; PFS, progression-free-survival. P values were calculated with log-rank test.
  2. Note. The event-rate was 51.7%, and 6 patients were alive without progression at the last follow-up (July 2008).
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BMC Cancer

ISSN: 1471-2407

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