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Table 2 Clinical and nutritional factors related to chemotherapy-induced toxicity development

From: Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study

 

Anemia

Neuropathy

Appetite loss

Nausea

Lymphopenia

Fatigue

All toxicities

Toxicity Grade III/IV

Gender

(Female vs male)

0.001

(38 vs 61.5)

0.03

(44 vs 55)

.851

0.09

(55 vs 46)

0.9

0.5

0.5

0.5

ECOG

(0,1 vs 2)

0.001

(32.6 vs 21.6)

0.7

0.022

(45 vs 63)

0.09

0.6

0.2

0.8

0.2

Diabetes

0.2

0.08

(51 vs 47)

0.1

0.5

0.3

0.6

0.2

0.8

Albumin

(>3.1 vs ≤3.0)

0.05

(47 vs 56)

0.06

(36 vs 64)

0.004

(46.7 vs 57.1)

0.07

(48 vs 54)

0.8

0.01

(46 vs 58)

0.002

(43 vs 62)

0.6

Weight loss

(>10% vs <9.9))

0.3

0.05

(23 vs 30)

0.4

0.7

0.039

(23.4 vs 30.9)

0.3

0.5

0.2

BMI

(≤19.9 vs >20)

0.006

(48 vs 76)

0.08

(49 vs 68)

0.4

0.8

0.2

0.2

1.0

0.6

SGA

(well nourished vs malnourished)

0.1

0.7

0.7

0.2

0.7

0.3

0.028

( 31 vs 22)

0.6

NLR

(≥5 vs ≤5)

0.1

0.8

0.2

0.8

-

0.8

0.2

0.7

PLR

(≥150 vs ≤150)

0.004

(37.9 vs 53.8)

0.8

0.7

0.4

-

0.2

0.2

.008

(59.3 vs 47)

  1. ECOG = Eastern Cooperative Oncology Group; BMI = Body Mass Index; SGA = Subjective Global Assessment; NLR = Neutrophil Lymphocyte Ratio; PLR = Platelet Lymphocyte Ratio