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Table 3 Statistical comparisons of TPD52 immunohistochemical staining in ovarian tissue samples

From: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

Tissue samples compared

Visual scoring

Automated scoring

 
  

Intensitya

Histoscoresb

SPCsb

 

Serous histology

Low-grade

4/5 (80%) v. 11/24 (46%)

182 (155-248) v. 181 (163-272)

260 (223-871) v. 237 (90-359)

 
 

carcinoma v.

NS, n = 29

NS, n = 29

NS, n = 34

 
 

borderline

    
 

High-grade

111/162 (69%) v. 11/24 (46%)

200 (96-285) v. 181 (163-272)

530 (166-1,059) v. 237 (90-359)

 
 

carcinoma v.

p = 0.038, n = 186

p = 0.038, n = 186

p < 0.001, n = 192

 
 

borderline

    

Mucinous histology

Carcinoma v.

8/10 (80%) v. 18/31 (58%)

236 (140-296) v. 216 (100-285)

384 (68-729) v. 125 (33-235)

 
 

borderline

NS, n = 41

NS, n = 41

NS, n = 29

 
 

Carcinoma v.

8/10 (80%) v. 2/6 (33%)

236 (140-296) v. 195 (140-225)

384 (68-729) v. 63 (8-131)

 
 

benign

NS, n = 16

NS, n = 16

p = 0.032, n = 17

 

Carcinomas

Serous v.

115/167 (69%) v. 9/19 (47%)

255 (171-291) v. 180 (90-285)

479 (190-848) v. 116 (22-337)

 
 

endometrioid

NS, n = 186

NS, n = 186

p = 0.003, n = 192

 
 

Serous v.

115/167 (69%) v. 8/10 (80%)

255 (171-291) v. 236 (140-296)

479 (190-848) v. 383 (69-729)

 
 

mucinous

NS, n = 177

NS, n = 177

NS, n = 182

 
 

Clear cell v.

8/8 (100%) v. 9/19 (47%)

288 (283-294) v. 180 (90-285)

534 (287-1,061) v. 116 (22-337)

 
 

endometrioid

p = 0.012, n = 27

p = 0.019, n = 27

p = 0.019, n = 28

 
 

Clear cell v.

8/8 (100%) v. 115/167 (69%)

288 (283-294) v. 255 (171-291)

534 (287-1,061) v. 479 (190-848)

 
 

serous

NS, n = 175

p = 0.028, n = 175

NS, n = 180

 
 

High-grade serous

111/162 (69%) v. 30/43 (70%)

255 (173-291) v. 264 (165-291)

480 (187-846) v. 274 (84-715)

 
 

v. others

NS, n = 205

NS, n = 205

p = 0.048, n = 211

 
  1. aComparisons of proportions (percentages) of samples with high level immunohistochemical staining, Fisher's Exact Test.
  2. bComparisons of median histoscores or strong pixel counts (SPCs, shown in thousands), Mann-Whitney Test. Compared median values (interquartile ranges) are shown.
  3. cNot statistically significant at p < 0.05.
  4. dValues in bold indicate associations that were significant when visual scores and digitally-determined SPCs were compared.
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BMC Cancer

ISSN: 1471-2407

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