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Table 3 Statistical comparisons of TPD52 immunohistochemical staining in ovarian tissue samples

From: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

Tissue samples compared Visual scoring Automated scoring  
   Intensitya Histoscoresb SPCsb  
Serous histology Low-grade 4/5 (80%) v. 11/24 (46%) 182 (155-248) v. 181 (163-272) 260 (223-871) v. 237 (90-359)  
  carcinoma v. NS, n = 29 NS, n = 29 NS, n = 34  
  borderline     
  High-grade 111/162 (69%) v. 11/24 (46%) 200 (96-285) v. 181 (163-272) 530 (166-1,059) v. 237 (90-359)  
  carcinoma v. p = 0.038, n = 186 p = 0.038, n = 186 p < 0.001, n = 192  
  borderline     
Mucinous histology Carcinoma v. 8/10 (80%) v. 18/31 (58%) 236 (140-296) v. 216 (100-285) 384 (68-729) v. 125 (33-235)  
  borderline NS, n = 41 NS, n = 41 NS, n = 29  
  Carcinoma v. 8/10 (80%) v. 2/6 (33%) 236 (140-296) v. 195 (140-225) 384 (68-729) v. 63 (8-131)  
  benign NS, n = 16 NS, n = 16 p = 0.032, n = 17  
Carcinomas Serous v. 115/167 (69%) v. 9/19 (47%) 255 (171-291) v. 180 (90-285) 479 (190-848) v. 116 (22-337)  
  endometrioid NS, n = 186 NS, n = 186 p = 0.003, n = 192  
  Serous v. 115/167 (69%) v. 8/10 (80%) 255 (171-291) v. 236 (140-296) 479 (190-848) v. 383 (69-729)  
  mucinous NS, n = 177 NS, n = 177 NS, n = 182  
  Clear cell v. 8/8 (100%) v. 9/19 (47%) 288 (283-294) v. 180 (90-285) 534 (287-1,061) v. 116 (22-337)  
  endometrioid p = 0.012, n = 27 p = 0.019, n = 27 p = 0.019, n = 28  
  Clear cell v. 8/8 (100%) v. 115/167 (69%) 288 (283-294) v. 255 (171-291) 534 (287-1,061) v. 479 (190-848)  
  serous NS, n = 175 p = 0.028, n = 175 NS, n = 180  
  High-grade serous 111/162 (69%) v. 30/43 (70%) 255 (173-291) v. 264 (165-291) 480 (187-846) v. 274 (84-715)  
  v. others NS, n = 205 NS, n = 205 p = 0.048, n = 211  
  1. aComparisons of proportions (percentages) of samples with high level immunohistochemical staining, Fisher's Exact Test.
  2. bComparisons of median histoscores or strong pixel counts (SPCs, shown in thousands), Mann-Whitney Test. Compared median values (interquartile ranges) are shown.
  3. cNot statistically significant at p < 0.05.
  4. dValues in bold indicate associations that were significant when visual scores and digitally-determined SPCs were compared.