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Table 2 Statistical comparisons of MAL2 immunohistochemical staining in ovarian tissue samples

From: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

  

Visual scoring

Automated scoringb

 

Tissue samples compared

Intensitya

Histoscoresb

  

Serous histology

Low-grade

2/7 (29%) v. 0/27 (0%)

100 (10-240) v. 86 (65-146)

422 (38-1,177) v. 235 (137-416)

 
 

carcinoma v.

p = 0.037, n = 34

NSc, n = 34

NS, n = 34

 
 

borderline

    
 

High-grade

100/175 (57%) v. 0/27 (0%)

255 (173-291) v. 86 (65-146)

480 (187-846) v. 235 (137-416)

 
 

carcinoma v.

p < 0.001, n = 202 d

p < 0.001, n = 202

p = 0.003, n = 192

 
 

borderline

    

Mucinous histology

Carcinoma v.

5/10 (50%) v. 3/32 (9%)

127 (0-296) v. 30 (0-79)

57 (18-768) v. 47 (27-132)

 
 

borderline

p = 0.012, n = 42

NS, n = 42

NS, n = 42

 
 

Carcinoma v.

5/10 (50%) v. 0/7 (0%)

127 (0-296) v. 0 (0-80)

57 (18-768) v. 224 (71-301)

 
 

benign

p = 0.044, n = 17

NS, n = 17

NS, n = 17

 

Carcinomas

Serous v.

102/182 (56%) v. 6/20 (30%)

198 (82-285) v. 93 (0-237)

528 (166-1,060) v. 72 (16-267)

 
 

endometrioid

p = 0.033, n = 202

p = 0.019, n = 202

p < 0.001, n = 192

 
 

Serous v.

102/182 (56%) v. 5/10 (50%)

198 (82-285) v. 127 (0-296)

528 (166-1,060) v. 57 (18-768)

 
 

mucinous

NS, n = 192

NS, n = 192

p = 0.030, n = 182

 
 

Clear cell v.

3/8 (38%) v. 6/20 (30%)

113 (40-249) v. 93 (0-237)

231 (133-661) v. 72 (16-267)

 
 

endometrioid

NS, n = 28

NS, n = 28

NS, n = 28

 
 

Clear cell v.

3/8 (38%) v. 102/182 (56%)

113 (40-249) v.198 (82-285)

231 (133-661) v. 528 (166-1,060)

 
 

serous

NS, n = 190

NS, n = 190

NS, n = 180

 
 

High-grade

100/175 (57%) v. 16/46 (35%)

200 (96-285) v. 110 (8-244)

531 (166-1,059) v. 124 (20-415)

 
 

serous v. others

p = 0.008, n = 221

p = 0.002, n = 221

p < 0.001, n = 211

 
  1. aComparisons of proportions (percentages) of samples with high level immunohistochemical staining, Fisher's Exact Test.
  2. bComparisons of median histoscores or strong pixel counts (SPCs, shown in thousands), Mann-Whitney Test. Median values (interquartile ranges) are shown.
  3. cNot statistically significant at p < 0.05.
  4. dValues in bold indicate associations that were significant when visual scores and digitally-determined SPCs were compared.
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BMC Cancer

ISSN: 1471-2407

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