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Table 2 Statistical comparisons of MAL2 immunohistochemical staining in ovarian tissue samples

From: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

   Visual scoring Automated scoringb  
Tissue samples compared Intensitya Histoscoresb   
Serous histology Low-grade 2/7 (29%) v. 0/27 (0%) 100 (10-240) v. 86 (65-146) 422 (38-1,177) v. 235 (137-416)  
  carcinoma v. p = 0.037, n = 34 NSc, n = 34 NS, n = 34  
  borderline     
  High-grade 100/175 (57%) v. 0/27 (0%) 255 (173-291) v. 86 (65-146) 480 (187-846) v. 235 (137-416)  
  carcinoma v. p < 0.001, n = 202 d p < 0.001, n = 202 p = 0.003, n = 192  
  borderline     
Mucinous histology Carcinoma v. 5/10 (50%) v. 3/32 (9%) 127 (0-296) v. 30 (0-79) 57 (18-768) v. 47 (27-132)  
  borderline p = 0.012, n = 42 NS, n = 42 NS, n = 42  
  Carcinoma v. 5/10 (50%) v. 0/7 (0%) 127 (0-296) v. 0 (0-80) 57 (18-768) v. 224 (71-301)  
  benign p = 0.044, n = 17 NS, n = 17 NS, n = 17  
Carcinomas Serous v. 102/182 (56%) v. 6/20 (30%) 198 (82-285) v. 93 (0-237) 528 (166-1,060) v. 72 (16-267)  
  endometrioid p = 0.033, n = 202 p = 0.019, n = 202 p < 0.001, n = 192  
  Serous v. 102/182 (56%) v. 5/10 (50%) 198 (82-285) v. 127 (0-296) 528 (166-1,060) v. 57 (18-768)  
  mucinous NS, n = 192 NS, n = 192 p = 0.030, n = 182  
  Clear cell v. 3/8 (38%) v. 6/20 (30%) 113 (40-249) v. 93 (0-237) 231 (133-661) v. 72 (16-267)  
  endometrioid NS, n = 28 NS, n = 28 NS, n = 28  
  Clear cell v. 3/8 (38%) v. 102/182 (56%) 113 (40-249) v.198 (82-285) 231 (133-661) v. 528 (166-1,060)  
  serous NS, n = 190 NS, n = 190 NS, n = 180  
  High-grade 100/175 (57%) v. 16/46 (35%) 200 (96-285) v. 110 (8-244) 531 (166-1,059) v. 124 (20-415)  
  serous v. others p = 0.008, n = 221 p = 0.002, n = 221 p < 0.001, n = 211  
  1. aComparisons of proportions (percentages) of samples with high level immunohistochemical staining, Fisher's Exact Test.
  2. bComparisons of median histoscores or strong pixel counts (SPCs, shown in thousands), Mann-Whitney Test. Median values (interquartile ranges) are shown.
  3. cNot statistically significant at p < 0.05.
  4. dValues in bold indicate associations that were significant when visual scores and digitally-determined SPCs were compared.