Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

Table 5 Univariate and multivariate analyses of various prognostic parameters in patients with SGC Cox-regression analysis

	Univariate analysis			Multivariate analysis
	No. patients	P	Regression coefficient (SE)	P	Relative risk	95% confidence interval
Clinical stage
I	16	<0.001	0.214(0.639)	0.003	1.894	1.244-2.884
II	58
III	39
IV	46
N classification
N0	118	<0.001	0.203(0.764)	<0.001	2.146	1.441-3.196
N1	21
N2	20
N3	0
Pathologic Differentiation
Poor	101	<0.001	0.168(0.358)	0.033	0.699	0.503-0.972
Moderate	4
Well	54
Expression of SPHK1
Low expression	74	0.001	0.324(0.657)	0.042	1.929	1.023-3.636
High expression	85

SPHK1 protein expression level in SGC significantly correlated with patient survival time (P < 0.001); the correlation coefficient was -0.363, indicating that higher levels of SPHK1 expression correlated with shorter survival time.

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