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Table 5 Univariate and multivariate analyses of various prognostic parameters in patients with SGC Cox-regression analysis

From: Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

  Univariate analysis Multivariate analysis
  No. patients P Regression coefficient (SE) P Relative risk 95% confidence interval
Clinical stage
I 16 <0.001 0.214(0.639) 0.003 1.894 1.244-2.884
II 58      
III 39      
IV 46      
N classification
N0 118 <0.001 0.203(0.764) <0.001 2.146 1.441-3.196
N1 21      
N2 20      
N3 0      
Pathologic Differentiation
Poor 101 <0.001 0.168(0.358) 0.033 0.699 0.503-0.972
Moderate 4      
Well 54      
Expression of SPHK1
Low expression 74 0.001 0.324(0.657) 0.042 1.929 1.023-3.636
High expression 85      
  1. SPHK1 protein expression level in SGC significantly correlated with patient survival time (P < 0.001); the correlation coefficient was -0.363, indicating that higher levels of SPHK1 expression correlated with shorter survival time.