Skip to main content
Figure 7 | BMC Cancer

Figure 7

From: Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation

Figure 7

Relationship of THBS4 methylation within the normal mucosa to pathology present elsewhere within the colorectum. THBS4 methylation within the normal mucosa with respect to the pathology present elsewhere within the colorectum was stratified by age (< 50 years, p = 0.018 and > 50 years, p = 0.0001). There was a significant trend evident in both groups p = 0.007 and p < 0.001 for young colorectum (< 50 yrs) and aged colorectum (> 50 yrs) respectively, indicating a significant inverse relationship between adenomatous pathology and THBS4 methylation. The lowest levels of THBS4 promoter methylation were associated with the most advanced pathology in both young and aged colorectal mucosa.

Back to article page