Figure 2From: Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation The THBS4 protein appears to be secreted. THBS4 protein is not expressed or is expressed at low levels in normal cells, especially towards the luminal surface. Tumour expression of THBS4 is heterogeneous, with generally no expression but occasional areas of strong expression and packaging in vesicular structures.Back to article page