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Table 5 Univariate and multivariate survival analysis.

From: Determining the role of external beam radiotherapy in unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 84 patients

Variables n Survival Status Univariate Multivariate
   1-Year
(n)
2-Year
(n)
Median survival (months) P RR P
Sex        
   Male 51 24.2 4.4 7.8 ± 1.6   1  
   Female 33 25.6 11.0 6.7 ± 0.5 0.862 1.054 0.845
Age        
   ≤60 years old 41 33.1 5.5 7.8 ± 1.6   1  
   >60 years old 43 16.5 8.2 6.7 ± 0.8 0.844 1.451 0.153
Clinical symptoms        
   Asymptomatic 15 21.8 6.7 6.7 ± 0.5   1  
   Symptomatic 69 66.7 19 13.1 ± 1.1 0.001 3.923 < 0.001
Diameter (cm)        
   ≤5 13 53.8 23.1 13.3 ± 2.8   1  
   5-10 39 15.0 3.0 6.8 ± 0.5   2.476 0.025
   ≥10 32 23.6 3.9 5.2 ± 0.4 0.013 3.165 0.011
Intrahepatic lesions        
   Solitary 63 26.6 7.1 6.8 ± 1.0   1  
   Multiple nodules 21 18.5 6.2 5.2 ± 0.7 0.604 1.794 0.050
Tumor types        
   Peripheral ICC 57 20.8 6.2 6.7 ± 1.0   1  
   Central ICC 27 31.9 8.0 6.8 ± 2.5 0.843 1.663 0.079
LN metastases        
   Asynchronous 13 69.2 15.4 14.2 ± 2.3   1  
   Synchronous 71 15.5 5.2 5.9 ± 0.7 0.002 1.794 0.025
CA19-9 (U/L)        
   ≤37 13 36.9 18.5 7.8 ± 2.4   1  
   37-600 26 32.6 4.1 9.6 ± 1.4   1.639 0.232
   ≥600 45 16.4 5.5 5.5 ± 0.7 0.307 1.343 0.451
EBRT        
   Yes 35 38.5 9.6 9.5 ± 1.1   1  
   No 49 14.6 4.9 5.1 ± 0.3 0.003 2.962 < 0.001
TACE        
   Yes 28 39.9 4.0 10.0 ± 1.4   1  
   No 56 16.6 8.3 5.9 ± 0.7 0.201 0.893 0.689
  1. RR, relative risk; ICC, intrahepatic cholangiocarcinoma; LN, lymph node; EBRT, external beam radiotherapy; TACE, transarterial chemoembolization.