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Table 1 Genes displaying differential expression between HB4a and C3.6 cell lines.

From: Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation

Symbol Ensembl Number and Description GO Biological Process Fold Change (at T0)
*ALDH1A3 ENSG00000184254:ALDEHYDE DEHYDROGENASE 6 GO:0006629:lipid metabolism 5.45
KRT15 ENSG00000171346:KERATIN, TYPE I CYTOSKELETAL 15 GO:0008544:epidermal differentiation 4.66
*AGR2 ENSG00000106541:ANTERIOR GRADIENT 2 Unknown 4.00
NCKAP1 ENSG00000061676:NCK-ASSOCIATED PROTEIN 1 (NAP 1) GO:0006915:apoptosis 3.87
COX6C ENSG00000164919:CYTOCHROME C OXIDASE POLYPEPTIDE VIC GO:0006091:energy pathways 3.37
PSCA ENSG00000167653:PROSTATE STEM CELL ANTIGEN PRECURSOR Unknown 2.94
*KRT13 ENSG00000171401:KERATIN, TYPE I CYTOSKELETAL 13 GO:0008544:epidermal differentiation 2.69
YWHAZ ENSG00000164924:14-3-3 PROTEIN ZETA/DELTA GO:0007165:signal transduction 2.47
*S100P ENSG00000163993:S-100P PROTEIN Unknown 2.45
*PKM2 ENSG00000067225:PYRUVATE KINASE, MUSCLE GO:0006096:glycolysis 2.41
TRAM1 ENSG00000067167:TRAM PROTEIN GO:0006605:protein targeting 2.38
ATP5L ENSG00000167283:ATP SYNTHASE G CHAIN, MITOCHONDRIAL GO:0015992:proton transport; GO:0006754:ATP biosynthesis 2.26
SLC7A7 ENSG00000155465:Y+L AMINO ACID TRANSPORTER 1 GO:0006832:small molecule transport 2.25
SSBP1 ENSG00000106028:SINGLE-STRANDED DNA-BINDING PROTEIN GO:0006260:DNA replication 2.25
SERF2 ENSG00000140264:SMALL EDRK-RICH FACTOR 2 Unknown 2.21
NEDD9 ENSG00000111859:ENHANCER OF FILAMENTATION 1 (HEF1) GO:0007155:cell adhesion; GO:0000074:regulation of cell cycle 2.18
SCAMP2 ENSG00000140497:SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2 GO:0006886:intracellular protein transport 2.12
EMP1 ENSG00000134531:EPITHELIAL MEMBRANE PROTEIN-1 GO:0007048:oncogenesis;GO:0008283:cell proliferation 2.10
*LCP1 ENSG00000136167:L-PLASTIN Unknown 2.09
MGST1 ENSG00000008394:MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 GO:0032496: response to lipopolysaccharide 2.06
DUT ENSG00000128951:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE GO:0006260:DNA replication 2.05
DDX5 ENSG00000108654:PROBABLE RNA-DEPENDENT HELICASE P68 GO:0016049:cell growth 2.00
SRP14 ENSG00000140319:SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN GO:0006605:protein targeting 1.98
*ANXA2 ENSG00000183059:ANNEXIN II (LIPOCORTIN II) GO:0001501:skeletal development 1.95
PBP ENSG00000089220:PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN Unknown 1.80
ATP5G3 ENSG00000154518:ATP SYNTHASE LIPID-BINDING PROTEIN GO:0006091:energy pathways; GO:0015992:proton transport 1.78
SRI ENSG00000075142:SORCIN (22 KDA PROTEIN) GO:0007517:muscle development 1.77
RPL17 ENSG00000141618:60S RIBOSOMAL PROTEIN L17 GO:0006412:protein biosynthesis 1.71
*ERBB2 ENSG00000141736:V-ERBB2 ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG 2 GO:0007169:transmembrane receptor protein tyrosine kinase signaling 1.67
*AKR1B1 ENSG00000085662:ALDOSE REDUCTASE GO:0005975:carbohydrate metabolism 1.66
ATP6V1F ENSG00000128524:VACUOLAR ATP SYNTHASE SUBUNIT F GO:0015992:proton transport; GO:0006754:ATP biosynthesis 1.66
ATP5G1 ENSG00000159199:ATP SYNTHASE LIPID-BINDING PROTEIN GO:0015992:proton transport 1.64
UBN1 ENSG00000118900:UBINUCLEIN 1 GO:0016568:chromatin modification 1.63
*ERBB3 ENSG00000065361:V-ERBB2 ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG 3 GO:0007169:transmembrane receptor protein tyrosine kinase signaling 1.62
FTH1 ENSG00000167996:FERRITIN HEAVY CHAIN GO:0008283:cell proliferation; GO:0006826:iron transport 1.62
ST14 ENSG00000149418:SUPPRESSOR OF TUMORIGENICITY 14 GO:0006508:proteolysis and peptidolysis 1.62
*PHB ENSG00000167085:PROHIBITIN GO:0008151:cell growth and/or maintenance 1.59
CLTC ENSG00000141367:CLATHRIN HEAVY CHAIN 1 GO:0006886:intracellular protein transport 1.51
APLP2 ENSG00000084234:AMYLOID-LIKE PROTEIN 2 PRECURSOR GO:0007186:G-protein coupled receptor protein signaling pathway 1.48
HSBP1 ENSG00000166530:HEAT SHOCK FACTOR BINDING PROTEIN 1 GO:0000122:negative regulation of transcription from Pol II promoter 1.48
*NME1 ENSG00000239672:NON-METASTATIC CELLS 1 GO:0045786:negative regulation of cell cycle; GO:0009142: NTP biosynthesis 1.47
*CPNE3 ENSG00000085719:COPINE III Unknown 1.46
*ISGF3G † ENSG00000213928:INTEREFERON REGULATORY FACTOR 9 GO:0006355:regulation of transcription; GO:0006955: immune response 0.73
*USP14 † ENSG00000101557:UBIQUITIN SPECIFIC PEPTIDASE 14 GO:0006511:ubiquitin-dependent protein catabolism 0.71
SSR4 ENSG00000180879:SIGNAL SEQUENCE RECEPTOR DELTA GO:0006886:intracellular protein transport 0.69
RAB7 ENSG00000075785:RAS-RELATED PROTEIN RAB-7 GO:0007264:small GTPase mediated signal transduction; GO:0006897:endocytosis 0.69
SHMT2 ENSG00000182199:SERINE HYDROXYMETHYLTRANSFERASE GO:0006520:amino acid metabolism 0.68
NGFRAP1 ENSG00000166681:NERVE GROWTH FACTOR RECEPTOR ASSOCIATED PROTEIN 1 GO:0007275:development; GO:0006915:apoptosis 0.66
HAT1 ENSG00000128708:HISTONE ACETYLTRANSFERASE 1 GO:0006323:DNA packaging; GO:0006475: internal protein amino acid acetylation 0.65
PPP1CA ENSG00000172531:SERINE/THREONINE PROTEIN PHOSPHATASE PP1-ALPHA 1 CATALYTIC SUBUNIT GO:0006470:protein amino acid dephosphorylation 0.65
UBL1 ENSG00000116030:UBIQUITIN-LIKE PROTEIN SMT3C PRECURSOR GO:0006281:DNA repair 0.65
NPC2 ENSG00000119655:EPIDIDYMAL SECRETORY PROTEIN E1 PRECURSOR GO:0000004:biological_process unknown 0.65
GMPS ENSG00000163655:GMP SYNTHASE GO:0006164:purine nucleotide biosynthesis 0.62
UBE2L6 † ENSG00000156587:UBIQUITIN-CONJUGATING ENZYME E2L 6 GO:0006512:ubiquitin cycle 0.61
SF3B1 NSG00000115524:SPLICING FACTOR 3B SUBUNIT 1 GO:0006371:mRNA splicing 0.58
ANXA1 ENSG00000135046:ANNEXIN I GO:0006928:cell motility;GO:0006629:lipid metabolism 0.57
SDC1 ENSG00000115884:SYNDICAN 1 GO:0048627:myoblast development 0.56
FXR1 ENSG00000114416:FRAGILE X MENTAL RETARDATION SYNDROME RELATED PROTEIN 1 GO:0006915:apoptosis 0.56
PLD3 ENSG00000105223:SIMILAR TO VACCINIA VIRUS HINDIII K4L ORF GO:0008152:metabolism 0.53
RPN1 ENSG00000163902:DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE GO:0006464:protein modification 0.51
*GSTP1 † ENSG00000084207:GLUTATHIONE S-TRANSFERASE P GO:0007417:central nervous system development 0.51
HDLBP ENSG00000115677:VIGILIN (HIGH DENSITY LIPOPROTEIN-BINDING PROTEIN) GO:0006869:lipid transport; GO:0008203:cholesterol metabolism 0.5
TYMS ENSG00000176890:THYMIDYLATE SYNTHASE GO:0006139:nucleobase, nucleoside, nucleotide and nucleic acid metabolism 0.44
WFDC2 ENSG00000101443:MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4 PRECURSOR GO:0006508:proteolysis and peptidolysis 0.43
OAS1 † ENSG00000089127:2',5'-OLIGOADENYLATE SYNTHETASE 1 GO:0006955:immune response 0.42
SERPINH1 ENSG00000149257:COLLAGEN-BINDING PROTEIN 2 PRECURSOR GO:0006950:response to stress 0.39
CYBA ENSG00000051523:CYTOCHROME B-245 ALPHA GO:0006118:electron transport; GO:0006801: superoxide metabolism 0.38
IFITM2 † ENSG00000185201:INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 2 GO:0006955:immune response 0.34
IGFBP3 ENSG00000146674:INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 PRECURSOR GO:0007165:signal transduction; GO:0001558:regulation of cell growth 0.31
ALDH1A1 ENSG00000165092:ALDEHYDE DEHYDROGENASE 1 FAMILY MEMBER A1 GO:0006081:aldehyde metabolism 0.29
IFITM1 † ENSG00000185885:INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 1 GO:0006955:immune response; GO:0008285:negative regulation of cell proliferation 0.25
*G1P2 † ENSG00000182106:UBIQUITIN CROSS-REACTIVE PRECURSOR GO:0006955:immune response; GO:0007267:cell-cell signaling 0.17
  1. Gene symbol, name, function and fold-change in expression (C3.6 vs. HB4a) at T0 are shown for genes displaying differential expression between cell lines and which were relatively unresponsive to growth factor. *Indicates that the protein product of this gene displays the same directionality of differential expression (data from 2D-DIGE and immunoblotting experiments ([38, 72, 78] and Figure 6)). Indicates the 8 down-regulated interferon-stimulated genes (ISGs).