Figure 6
Schematic diagram representing the role of ADAMTS1 in epithelial cell invasion and endothelial cell proliferation. ADAMTS1 expression is elevated in the epithelial cells of endometrial adenocarcinoma by PGF2α-FP receptor signalling to the calmodulin-NFAT pathway. In turn ADAMTS1 acts in an autocrine/paracrine manner on tumour epithelial cells to regulate epithelial cell invasion through ECM. Moreover, ADAMTS1 secreted from epithelial cells acts in a paracrine manner on endothelial cells to inhibit cellular proliferation. In addition factors present in the conditioned medium from PGF2α- treated epithelial cells upregulates endothelial ADAMTS1 which in turn can act in an autocrine/paracrine manner to inhibit endothelial cell proliferation.