Table 6 Interaction between gene polymorphisms and NSAID use.
From: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes
NSAID | IRRA95% CI | IRRB95% CI | p-valueC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NO | YES | NSAID | NSAID | ||||||||||
N C | NS | NC | NS | NO | YES | NO | YES | ||||||
NFkB -94ins/del | |||||||||||||
II | 83 | 210 | 38 | 97 | 1.00 | - | 1.09 | (0.69-1.73) | 1.00 | - | 1.03 | (0.64-1.65) | 0.82 |
ID and DD | 172 | 312 | 85 | 137 | 1.47 | (1.06-2.03) | 1.60 | (1.09-2.35) | 1.43 | (1.02-1.99) | 1.55 | (1.04-2.31) | |
PXR rs1523127 | |||||||||||||
AA | 83 | 172 | 44 | 85 | 1.00 | - | 1.09 | (0.69-1.73) | 1.00 | - | 1.07 | (0.67-1.71) | 0.99 |
AC and CC | 172 | 350 | 79 | 149 | 1.01 | (0.73-1.40) | 1.11 | (0.75-1.63) | 1.02 | (0.73-1.43) | 1.09 | (0.73-1.63) | |
PXR rs2276707 | |||||||||||||
CC | 161 | 296 | 76 | 145 | 1.00 | - | 1.01 | (0.72-1.43) | 1.00 | - | 0.96 | (0.67-1.37) | 0.25 |
CT and TT | 94 | 226 | 47 | 89 | 0.81 | (0.59-1.12) | 1.01 | (0.67-1.53) | 0.81 | (0.59-1.12) | 1.02 | (0.66-1.56) | |
PXR rs6785049 | |||||||||||||
AA | 90 | 180 | 46 | 79 | 1.00 | - | 1.11 | (0.70-1.74) | 1.00 | - | 1.07 | (0.67-1.71) | 0.98 |
AG and GG | 165 | 342 | 77 | 155 | 0.96 | (0.69-1.32) | 1.04 | (0.71-1.53) | 0.94 | (0.67-1.32) | 1.00 | (0.67-1.49) | |
LXR rs1405655 | |||||||||||||
CC | 117 | 238 | 52 | 109 | 1.00 | - | 1.00 | (0.67-1.50) | 1.00 | - | 0.94 | (0.62-1.44) | 0.32 |
CT and TT | 138 | 284 | 71 | 125 | 0.96 | (0.71-1.31) | 1.13 | (0.78-1.65) | 0.95 | (0.69-1.30) | 1.12 | (0.76-1.64) | |
LXR rs2695121 | |||||||||||||
TT | 85 | 161 | 32 | 60 | 1.00 | - | 1.08 | (0.64-1.80) | 1.00 | - | 1.02 | (0.58-1.78) | 0.75 |
CT and CC | 170 | 361 | 91 | 174 | 0.87 | (0.62-1.21) | 0.97 | (0.67-1.41) | 0.84 | (0.60-1.19) | 0.93 | (0.63-1.36) | |