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Table 6 Interaction between gene polymorphisms and NSAID use.

From: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

  NSAID IRRA95% CI IRRB95% CI p-valueC
  NO YES NSAID NSAID  
  N C NS NC NS NO YES NO YES  
NFkB -94ins/del              
   II 83 210 38 97 1.00 - 1.09 (0.69-1.73) 1.00 - 1.03 (0.64-1.65) 0.82
   ID and DD 172 312 85 137 1.47 (1.06-2.03) 1.60 (1.09-2.35) 1.43 (1.02-1.99) 1.55 (1.04-2.31)  
PXR rs1523127              
   AA 83 172 44 85 1.00 - 1.09 (0.69-1.73) 1.00 - 1.07 (0.67-1.71) 0.99
   AC and CC 172 350 79 149 1.01 (0.73-1.40) 1.11 (0.75-1.63) 1.02 (0.73-1.43) 1.09 (0.73-1.63)  
PXR rs2276707              
   CC 161 296 76 145 1.00 - 1.01 (0.72-1.43) 1.00 - 0.96 (0.67-1.37) 0.25
   CT and TT 94 226 47 89 0.81 (0.59-1.12) 1.01 (0.67-1.53) 0.81 (0.59-1.12) 1.02 (0.66-1.56)  
PXR rs6785049              
   AA 90 180 46 79 1.00 - 1.11 (0.70-1.74) 1.00 - 1.07 (0.67-1.71) 0.98
   AG and GG 165 342 77 155 0.96 (0.69-1.32) 1.04 (0.71-1.53) 0.94 (0.67-1.32) 1.00 (0.67-1.49)  
LXR rs1405655              
   CC 117 238 52 109 1.00 - 1.00 (0.67-1.50) 1.00 - 0.94 (0.62-1.44) 0.32
   CT and TT 138 284 71 125 0.96 (0.71-1.31) 1.13 (0.78-1.65) 0.95 (0.69-1.30) 1.12 (0.76-1.64)  
LXR rs2695121              
   TT 85 161 32 60 1.00 - 1.08 (0.64-1.80) 1.00 - 1.02 (0.58-1.78) 0.75
   CT and CC 170 361 91 174 0.87 (0.62-1.21) 0.97 (0.67-1.41) 0.84 (0.60-1.19) 0.93 (0.63-1.36)  
  1. ACrude (adjusted for age and sex)
  2. BAdditionally adjusted for status of hormone replacement therapy (HRT), smoking status, alcohol, dietary fibre, red meat, physical activity and BMI.
  3. C P-value for interaction for the adjusted estimates.
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