Skip to main content

Table 5 Interaction between the studied polymorphisms and smoking status.

From: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

  Smoking IRRA95% CI p-valueB
  Never Past Current Smoking  
  NC NS NC NS NC NS Never Past Current  
NFkB -94ins/del              
   II 37 101 37 101 47 105 1.00 - 0.89 (0.51-1.55) 1.15 (0.67-1.97) 0.84
   ID and DD 79 149 76 137 102 163 1.45 (0.89-2.37) 1.41 (0.86-2.33) 1.55 (0.96-2.51)  
PXR rs1523127              
   AA 33 94 42 76 52 87 1.00 - 1.37 (0.77-2.47) 1.55 (0.89-2.70) 0.08
   AC and CC 83 156 71 162 97 181 1.49 (0.90-2.45) 1.15 (0.69-1.91) 1.38 (0.84-2.28)  
PXR rs2276707              
   CC 63 141 70 135 104 165 1.00 - 1.01 (0.65-1.57) 1.24 (0.82-1.87) 0.43
   CT and TT 53 109 43 103 45 103 1.06 (0.66-1.68) 0.89 (0.54-1.47) 0.93 (0.57-1.51)  
PXR rs6785049              
   AA 40 89 38 85 58 85 1.00 - 0.92 (0.52-1.61) 1.37 (0.80-2.33) 0.28
   AG and GG 76 161 75 153 91 183 1.06 (0.65-1.72) 1.00 (0.61-1.63) 1.04 (0.64-1.67)  
LXR rs1405655              
   CC 49 117 54 116 66 114 1.00 - 0.93 (0.56-1.54) 1.18 (0.72-1.92) 0.83
   CT and TT 67 133 59 122 83 154 1.07 (0.66-1.72) 1.01 (0.62-1.64) 1.11 (0.71-1.74)  
LXR rs2695121              
   TT 36 74 35 63 46 84 1.00 - 1.12 (0.61-2.07) 1.20 (0.67-2.13) 0.67
   CT and CC 80 176 78 175 103 184 0.98 (0.59-1.63) 0.85 (0.51-1.42) 1.03 (0.63-1.70)  
  1. AAdjusted for age, sex, status of hormone replacement therapy (HRT)(women only), alcohol, dietary fibre and BMI, physical activity and NSAID use.
  2. B P-value for interaction.