Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

BMC Cancer

Table 2 Incidence rate ratios (IRR) for colorectal cancer for the studied gene polymorphisms.

	N_cases	N_sub-cohort	IRR^A	95% CI	IRR^B	95% CI	p-value^C
NFkB -94ins/del
II	121	307	1.00	-	1.00	-	0.03
ID	195	347	1.46	(1.10-1.93)	1.44	(1.07-1.92)
DD	62	102	1.50	(1.02-2.22)	1.50	(1.00-2.25)
ID and DD	257	449	1.47	(1.12-1.92)	1.45	(1.10-1.92)
PXR rs1523127
AA	127	257	1.00	-	1.00	-	0.78
AC	188	371	0.99	(0.74-1.31)	0.99	(0.74-1.32)
CC	63	128	1.08	(0.74-1.57)	1.12	(0.77-1.65)
AC and CC	251	499	1.01	(0.77-1.32)	1.02	(0.77-1.34)
PXR rs2276707
CC	237	441	1.00	-	1.00	-	0.66
CT	122	270	0.87	(0.67-1.14)	0.88	(0.67-1.17)
TT	19	45	0.83	(0.46-1.49)	0.89	(0.49-1.62)
CT and TT	141	315	0.87	(0.67-1.12)	0.88	(0.68-1.15)
PXR rs6785049
AA	136	259	1.00	-	1.00	-	0.60
AG	187	398	0.91	(0.69-1.21)	0.90	(0.67-1.21)
GG	55	99	1.10	(0.74-1.64)	1.09	(0.72-1.65)
AG and GG	242	497	0.95	(0.73-1.24)	0.94	(0.71-1.24)
LXR rs1405655
CC	169	347	1.00	-	1.00	-	0.88
CT	169	335	1.00	(0.77-1.31)	1.00	(0.76-1.31)
TT	40	74	1.05	(0.68-1.63)	1.12	(0.71-1.76)
CT and TT	209	409	1.01	(0.79-1.31)	1.02	(0.79-1.32)
LXR rs2695121
TT	117	221	1.00	-	1.00	-	0.36
CT	187	368	0.93	(0.69-1.25)	0.91	(0.67-1.23)
CC	74	167	0.78	(0.54-1.12)	0.77	(0.53-1.11)
CT and CC	261	535	0.88	(0.67-1.17)	0.86	(0.65-1.15)

^ACrude (adjusted for age and sex).
^BAdditionally adjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, red meat, physical activity and BMI and NSAID use.
^Cp-value for trend for the adjusted estimates.

ISSN: 1471-2407