Skip to main content

Table 2 Incidence rate ratios (IRR) for colorectal cancer for the studied gene polymorphisms.

From: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

  Ncases Nsub-cohort IRRA 95% CI IRRB 95% CI p-valueC
NFkB -94ins/del        
   II 121 307 1.00 - 1.00 - 0.03
   ID 195 347 1.46 (1.10-1.93) 1.44 (1.07-1.92)  
   DD 62 102 1.50 (1.02-2.22) 1.50 (1.00-2.25)  
   ID and DD 257 449 1.47 (1.12-1.92) 1.45 (1.10-1.92)  
PXR rs1523127        
   AA 127 257 1.00 - 1.00 - 0.78
   AC 188 371 0.99 (0.74-1.31) 0.99 (0.74-1.32)  
   CC 63 128 1.08 (0.74-1.57) 1.12 (0.77-1.65)  
   AC and CC 251 499 1.01 (0.77-1.32) 1.02 (0.77-1.34)  
PXR rs2276707        
   CC 237 441 1.00 - 1.00 - 0.66
   CT 122 270 0.87 (0.67-1.14) 0.88 (0.67-1.17)  
   TT 19 45 0.83 (0.46-1.49) 0.89 (0.49-1.62)  
   CT and TT 141 315 0.87 (0.67-1.12) 0.88 (0.68-1.15)  
PXR rs6785049        
   AA 136 259 1.00 - 1.00 - 0.60
   AG 187 398 0.91 (0.69-1.21) 0.90 (0.67-1.21)  
   GG 55 99 1.10 (0.74-1.64) 1.09 (0.72-1.65)  
   AG and GG 242 497 0.95 (0.73-1.24) 0.94 (0.71-1.24)  
LXR rs1405655        
   CC 169 347 1.00 - 1.00 - 0.88
   CT 169 335 1.00 (0.77-1.31) 1.00 (0.76-1.31)  
   TT 40 74 1.05 (0.68-1.63) 1.12 (0.71-1.76)  
   CT and TT 209 409 1.01 (0.79-1.31) 1.02 (0.79-1.32)  
LXR rs2695121        
   TT 117 221 1.00 - 1.00 - 0.36
   CT 187 368 0.93 (0.69-1.25) 0.91 (0.67-1.23)  
   CC 74 167 0.78 (0.54-1.12) 0.77 (0.53-1.11)  
   CT and CC 261 535 0.88 (0.67-1.17) 0.86 (0.65-1.15)  
  1. ACrude (adjusted for age and sex).
  2. BAdditionally adjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, red meat, physical activity and BMI and NSAID use.
  3. Cp-value for trend for the adjusted estimates.