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Figure 5 | BMC Cancer

Figure 5

From: 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

Figure 5

17-AAG activates Caspase-dependent death processes in bladder cancer cells. Apoptotic death induced by 17-AAG administration in human urinary bladder cancer cells was characterized by reduced expression and proteolytic cleavage profiles of apoptosis-related proteins, in response to various drug concentrations, for 24-hours exposure period. Treatment of RT4, RT112 and T24 cells with 17-AAG resulted in prominent cleavage and activation of critical members of the Caspase apoptotic machinery in all three cell lines, along with notable proteolytic processing of the Caspase repertoire characteristic substrates PARP and Lamin A/C. All apoptosis immunoblotting experiments were repeated three times.

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BMC Cancer

ISSN: 1471-2407

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