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Table 4 Individual course of disease of BM patients

From: Extracerebral metastases determine the outcome of patients with brain metastases from renal cell carcinoma

Patient

MSKCC risk group

ECOG performance status at diagnosis of BM

Extracerebral metastatic site

TX prior first TA

Time from primary metastasis to BM

(months)

BM-TX

CNS recurrence during/after TA

First TA

Best Response

PFS

Following TX lines

OS

Progressing metastatic site leading to death

1

fav

0

Lung

Cytokines

0

surg

no

SU

CR

24.2

Ongoing

24.2

non progressing and alive

2

interm

0

Lung

Cytokines, Capecitabin

45

surg

no

Beva

SD

8.7

SU

Soraf

Tems

Tems+Beva

46.9

non progressing and alive

3

interm

1

lung, LN

no

0

surg, WBRT

no

SU

SD

8.5

ongoing

8.5

non progressing and alive

4

interm

1

lung, other

Cytokines

72

SR

no

Beva

SD

21.6

SU, Tems

36.9

lung, liver

5

fav

0

liver, bone, other

Cytokines, Navelbine

27

WBRT, SR

yes (progression in lesion size)

Soraf

PD

2.6

SU

13.42

lung.

6

interm

1

other

no

0

SR, WBRT

yes (progression in lesion size)

SU

PD

3.4

Tems, Beva +Interferon

10.16

Liver

7

interm

0

Ln

no

0

WBRT

no

SU

PR

3.26

Soraf

18.82

non progressing and alive

8

interm

1

lung

no

0

Surg, SR

no

SU

SD

12.1

SU

40.6

non progressing and alive

9

interm

1

lung, liver, other

no

0

SR

no

Tems

SD

6.3

no

6.3

liver, lung

10

interm

0

lung, ln

no

8

WBRT

no

Soraf

PR

10.9

no

10.9

Lung

11

interm

0

lung, other

Cytokines, Navelbine

14

Surg,WBRT

yes (relapse of resected lesion and new lesions)

SU

SD

3.8

no

3.8

cranial vertebral fractures

12

poor

2

bone

no

0

WBRT

No

SU

SD

6.7

no

6.7

Lung

  1. MSKCC = Memorial Sloan-Kettering Center Center
  2. fav = favourable risk
  3. interm = intermediate risk
  4. poor = poor risk
  5. ECOG = Eastern Cooperative Oncology Group
  6. TX = treatment
  7. TA = targeted agent
  8. BM = brain metastasis
  9. SR = stereotactic radiation
  10. WBRT = whole brain radiation therapy
  11. Surg = surgery
  12. SU = Sunitinib
  13. Soraf = Sorafenib
  14. Tems = Temsirolimus
  15. Beva = Bevacizumab
  16. CR = complete remission
  17. PR = partial remission
  18. SD = stable disease
  19. PD = progressive disease
  20. PFS = progression free survival
  21. OS = overall survival