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Table 4 Individual course of disease of BM patients

From: Extracerebral metastases determine the outcome of patients with brain metastases from renal cell carcinoma

Patient MSKCC risk group ECOG performance status at diagnosis of BM Extracerebral metastatic site TX prior first TA Time from primary metastasis to BM
(months)
BM-TX CNS recurrence during/after TA First TA Best Response PFS Following TX lines OS Progressing metastatic site leading to death
1 fav 0 Lung Cytokines 0 surg no SU CR 24.2 Ongoing 24.2 non progressing and alive
2 interm 0 Lung Cytokines, Capecitabin 45 surg no Beva SD 8.7 SU
Soraf
Tems
Tems+Beva
46.9 non progressing and alive
3 interm 1 lung, LN no 0 surg, WBRT no SU SD 8.5 ongoing 8.5 non progressing and alive
4 interm 1 lung, other Cytokines 72 SR no Beva SD 21.6 SU, Tems 36.9 lung, liver
5 fav 0 liver, bone, other Cytokines, Navelbine 27 WBRT, SR yes (progression in lesion size) Soraf PD 2.6 SU 13.42 lung.
6 interm 1 other no 0 SR, WBRT yes (progression in lesion size) SU PD 3.4 Tems, Beva +Interferon 10.16 Liver
7 interm 0 Ln no 0 WBRT no SU PR 3.26 Soraf 18.82 non progressing and alive
8 interm 1 lung no 0 Surg, SR no SU SD 12.1 SU 40.6 non progressing and alive
9 interm 1 lung, liver, other no 0 SR no Tems SD 6.3 no 6.3 liver, lung
10 interm 0 lung, ln no 8 WBRT no Soraf PR 10.9 no 10.9 Lung
11 interm 0 lung, other Cytokines, Navelbine 14 Surg,WBRT yes (relapse of resected lesion and new lesions) SU SD 3.8 no 3.8 cranial vertebral fractures
12 poor 2 bone no 0 WBRT No SU SD 6.7 no 6.7 Lung
  1. MSKCC = Memorial Sloan-Kettering Center Center
  2. fav = favourable risk
  3. interm = intermediate risk
  4. poor = poor risk
  5. ECOG = Eastern Cooperative Oncology Group
  6. TX = treatment
  7. TA = targeted agent
  8. BM = brain metastasis
  9. SR = stereotactic radiation
  10. WBRT = whole brain radiation therapy
  11. Surg = surgery
  12. SU = Sunitinib
  13. Soraf = Sorafenib
  14. Tems = Temsirolimus
  15. Beva = Bevacizumab
  16. CR = complete remission
  17. PR = partial remission
  18. SD = stable disease
  19. PD = progressive disease
  20. PFS = progression free survival
  21. OS = overall survival