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Figure 5 | BMC Cancer

Figure 5

From: Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors

Figure 5

Tumor transplantation site significantly alters the gene expression profiles of the SRC tumors. Since the SRC tumors at different transplant sites originated from the same source tumor, the unique SRC gene expression profiles at each transplant site are likely a result of interactions in the microenvironment between tumor cells and host cells. For each gene expression comparison (A-C), a different tumor was selected as a "reference sample"(highlighted in yellow). The gene expression of the "reference sample" was then compared with the gene expression profiles of the other tumors. For each comparison, the upregulation/downregulation refers to the status of the genes in the "reference sample" compared to the tumor samples. (A) Differential gene expression between the Subcutaneous SRC tumor (reference sample; highlighted in yellow) and SRC tumors at the other transplantation sites (200 genes upregulated; 107 genes downregulated in the Subcutaneous SRC tumor). (B) Differential gene expression between the Tibia SRC tumor (reference sample; highlighted in yellow) and the SRC tumors at the other transplantation sites (106 genes upregulated; 108 genes downregulated in the tibia SRC tumor). (C) Differential gene expression between the Lung SRC tumor (reference sample; highlighted in yellow) and the SRC tumors at the other transplantation sites (157 genes upregulated; 73 genes downregulated in the lung SRC tumor). Color bar illustrates relative gene expression levels. See "Methods" for additional description (Gene expression comparisons between SRC tumors), and see Additional file 3 for complete data set and annotation of the genes presented within this figure.

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