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Table 2 Clinicopathological characteristics and toxicity profile of DPYD mutation carriers

From: Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients

  Patient #1 Patient #2 Patient #3
Age 35 64 68
Gender female male female
Tumor    
   Location Colorectal Colorectal Esophageal
   Type Adenocarcinoma Adenocarcinoma Squamous cell carcinoma
   Stage IV IIIB IV
Treatment regimen    
Toxicity profile    
   Mucositis G3 G4 G4
   Anemia G4 G0 G0
   Neutropenia G4 G4 G0
   Thrombocytopenia G4 G0 G0
DPYD mutation type 1845 G > T IVS14+1G > A IVS14+1G > A