Table 2 Clinicopathological characteristics and toxicity profile of DPYD mutation carriers
Patient #1 | Patient #2 | Patient #3 | |
|---|---|---|---|
Age | 35 | 64 | 68 |
Gender | female | male | female |
Tumor | |||
Location | Colorectal | Colorectal | Esophageal |
Type | Adenocarcinoma | Adenocarcinoma | Squamous cell carcinoma |
Stage | IV | IIIB | IV |
Treatment regimen | |||
Toxicity profile | |||
Mucositis | G3 | G4 | G4 |
Anemia | G4 | G0 | G0 |
Neutropenia | G4 | G4 | G0 |
Thrombocytopenia | G4 | G0 | G0 |
DPYD mutation type | 1845 G > T | IVS14+1G > A | IVS14+1G > A |