Novel genetic variants in miR-191 gene and familial ovarian cancer

BMC Cancer

Table 1 Novel Genetic variants in selected miRNA genes in ovarian cancer patients

miRNA genes	Nt Change	Location	Allele frequency	Selected target genes (examples)*
miR -17	C/T	Pri-miRNA	0.012	BRCA1, PTEN, p53 and ATM
hsa-mir-191	C/T	Pri-miRNA	0.006	IGF1R, FANCC, FANCF, FANCD2, MLH3
	C/G	pri-miRNA	0.012
	C/A	Pre-miRNA	0.006
hsa-mir-29b-2	C/T	pri-miRNA	0.042	DNMT3A, IGFI, CCND2, BCL2
	A/T	pre-miRNA	0.021	DNMT3A, IGFI, CCND2, BCL2
hsa-mir-188	T/C	pri-miRNA	0.006	CCND2, XRCC2, IGFI, E2F

* This non-inclusive list shows only the potential targets known to be involved in tumorigenesis. Other, unrelated, targets may exist for these miRNAs.

ISSN: 1471-2407