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Table 2 Pharmacokinetic parameters calculated after intravenous and intraperitoneal bolus infusion

From: Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study

 

i.v. infusion

i.p. infusion

 

Vein

XP

Peritoneum

Vein

XP

Muscle

AUC (μM × min)

202 (144-1038)

311 (258-378)

347 (219-425)

170 (105-229)

246 (165-534)

234 (160-321)

t½ (min)

41.7 (34.2-54.6)

39.0 (26.2-50.4)

42.2 (25.4-51.2)

   

Cmax (μM)

5.0 (3.8-51.2)

6.6 (5.8-8.3)

7.4 (3.7-7.9)

1.5 (1.3-1.9)

2.4 (1.9-4.1)

2.1 (1.4-2.9)

tmax (min)

20-30

20-30

20-30

40-50

40-50

40-50

  1. XP = extraperitoneal space, AUC = area under the curve, t½ = half-life, Cmax = maximal concentration, tmax = time after start of infusion until maximal concentration with time intervals of 10 min.
  2. The results are expressed as median (range) from six animals in the i.v. group and five animals in the i.p. group. For tmax, the results represent the time interval with maximal concentration.
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BMC Cancer

ISSN: 1471-2407

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