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Figure 3 | BMC Cancer

Figure 3

From: Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study

Figure 3

a. Intravenous bolus infusion and b. Intraperitoneal bolus infusion. a. Semilogaritmic concentration vs. time curves of mitomycin C (MMC) from microdialysis probes placed in vein (V), the extraperitoneal space (XP) and intraperitoneally (P) after 30 min i.v. infusion. Microdialysis sampling started six minutes after start of infusion to allow emptying of dead volume in microdialysis probes. The results are presented as mean (+ SD) from six experiments. The filled circles in the V diagram represent total serum MMC concentrations (+ SD). b. Semilogaritmic concentration vs. time curves of MMC from microdialysis probes placed in V, XP and hind leg muscle (M) after 30 min i.p. infusion. Microdialysis sampling started six minutes after start of infusion to allow emptying of dead volume in microdialysis probes. The results are presented as mean (+ SD) from five experiments. The filled circles in the V diagram represent total serum MMC concentrations (+ SD).

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