Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age

Table 5 Comparison of individual BRCA2 variant frequencies

Variant	rs number	Codon Change	Deleterious mutation non-carriers	Deleterious mutation carriers	Chi square (Permutation)	P value (Permutation)
1342 A > C	rs6004238	N372H	0.338	0.042	4.095	0.043
3642 A > G	rs1801406	K1132K	0.141	0.000	1.392	0.238
4035 T > C	rs543304	V1269V	0.123	0.042	0.215	0.643
7470 A > G	rs1799955	S2414S	0.111	0.000	0.845	0.358
Overall					6.547	0.162

ISSN: 1471-2407