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Table 3 Cooperations of Aurora B and Aurora A mRNA expressions in relation to clinicopathologic and molecular features in 160 patients with primary unifocal HCC

From: Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

Feature Aurora B / Aurora A expression number (%) P value
  +/+ (n = 72) +/- (n = 26) -/+ (n = 28) -/- (n = 34)  
AFP      < 0.0001
   < 200 21 (29) 12 (46) 18 (64) 29 (85)  
   ≥200 51 (71) 14 (54) 10 (36) 5 (15)  
Size (cm)      < 0.0001
   ≤5 20 (28) 17 (65) 11 (39) 24 (71)  
   > 5 52 (72) 9 (35) 17 (61) 10 (29)  
Grade      0.0014
   I 4 (6) 6 (23) 8 (29) 13 (38)  
   II 36 (50) 12 (46) 10 (36) 16 (47)  
   III-IV 32 (44) 8 (31) 10 (36) 5 (15)  
Stage      < 0.0001
   I-II 13 (18) 8 (31) 16 (57) 29 (85)  
   IIIA-IV 59 (82) 18 (69) 12 (43) 5 (15)  
p53 mutation      0.0099
   No 22 (36) 12 (52) 15 (65) 19 (70)  
   Yes 39 (64) 11 (48) 8 (35) 8 (30)  
β-catenin mutation      0.0024
   No 61 (92) 24 (92) 23 (85) 20 (65)  
   Yes 5 (8) 2 (8) 4 (15) 11 (35)  
ETR      < 0.0001
   No 17 (26) 11 (46) 19 (70) 29 (88)  
   Yes 48 (74) 13 (54) 8 (30) 4 (12)  
5-year survival      0.0003
   Yes 14 (19) 8 (31) 15 (54) 19 (56)  
   No 58 (81) 18 (69) 13 (46) 15 (44)  
  1. Abbreviation: +, present; -, absent