Table 3 Cooperations of Aurora B and Aurora A mRNA expressions in relation to clinicopathologic and molecular features in 160 patients with primary unifocal HCC
From: Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
Feature | Aurora B / Aurora A expression number (%) | P value | |||
|---|---|---|---|---|---|
| Â | +/+ (n = 72) | +/- (n = 26) | -/+ (n = 28) | -/- (n = 34) | Â |
AFP | Â | Â | Â | Â | < 0.0001 |
   < 200 | 21 (29) | 12 (46) | 18 (64) | 29 (85) |  |
   ≥200 | 51 (71) | 14 (54) | 10 (36) | 5 (15) |  |
Size (cm) | Â | Â | Â | Â | < 0.0001 |
   ≤5 | 20 (28) | 17 (65) | 11 (39) | 24 (71) |  |
   > 5 | 52 (72) | 9 (35) | 17 (61) | 10 (29) |  |
Grade | Â | Â | Â | Â | 0.0014 |
   I | 4 (6) | 6 (23) | 8 (29) | 13 (38) |  |
   II | 36 (50) | 12 (46) | 10 (36) | 16 (47) |  |
   III-IV | 32 (44) | 8 (31) | 10 (36) | 5 (15) |  |
Stage | Â | Â | Â | Â | < 0.0001 |
   I-II | 13 (18) | 8 (31) | 16 (57) | 29 (85) |  |
   IIIA-IV | 59 (82) | 18 (69) | 12 (43) | 5 (15) |  |
p53 mutation | Â | Â | Â | Â | 0.0099 |
   No | 22 (36) | 12 (52) | 15 (65) | 19 (70) |  |
   Yes | 39 (64) | 11 (48) | 8 (35) | 8 (30) |  |
β-catenin mutation |  |  |  |  | 0.0024 |
   No | 61 (92) | 24 (92) | 23 (85) | 20 (65) |  |
   Yes | 5 (8) | 2 (8) | 4 (15) | 11 (35) |  |
ETR | Â | Â | Â | Â | < 0.0001 |
   No | 17 (26) | 11 (46) | 19 (70) | 29 (88) |  |
   Yes | 48 (74) | 13 (54) | 8 (30) | 4 (12) |  |
5-year survival | Â | Â | Â | Â | 0.0003 |
   Yes | 14 (19) | 8 (31) | 15 (54) | 19 (56) |  |
   No | 58 (81) | 18 (69) | 13 (46) | 15 (44) |  |