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Table 3 Comparison between histopathological or molecular parameters and response to therapy

From: Molecular alterations in key-regulator genes among patients with T4 breast carcinoma

A

               

Outcome

ER

PR

Ki67

HER2

   
 

positives

%

P

positives

%

P

positives

%

P

positives

%

P

   

Clinical response

  

0.132

  

0.640

  

0.047

  

0.022

   

   Complete response

3/7

43

 

3/7

43

 

5/7

71

 

8/8

100

    

Partial response

16/29

55

 

11/29

38

 

9/27

33

 

27/37

73

    

< Partial response

5/8

62

 

2/8

25

 

2/8

25

 

2/8

25

    

Pathological response

  

0.469

  

0.235

  

0.042

  

0.095

   

pCR

4/7

57

 

3/7

43

 

5/7

71

 

7/8

87

    

<pCR

20/37

54

 

13/37

35

 

11/35

31

 

30/45

67

    

B

               

Outcome

cyclinD1

h-prune

pERK 1-2

p53

survivin

 

positives

%

P

positives

%

P

positives

%

P

positives

%

P

   

Clinical response

  

0.457

  

0.824

  

0.032

  

0.391

  

0.089

   Complete response

1/8

12

 

1/8

12

 

0/8

0

 

1/8

12

 

1/8

12

 

Partial response

8/37

22

 

5/37

14

 

3/37

8

 

10/37

27

 

15/37

41

 

< Partial response

3/8

37

 

2/8

25

 

2/8

25

 

2/8

25

 

5/8

62

 

Pathological response

  

0.660

  

0.822

  

0.007

  

0.972

  

0.234

pCR

2/8

25

 

1/8

12

 

0/8

0

 

2/8

25

 

3/8

37

 

<pCR

10/45

22

 

7/45

16

 

5/45

11

 

11/45

24

 

18/45

40

 
  1. pCR, pathological complete response