Figure 7

Cross species comparative-KC-SMART analyses. (a) The upper section shows the KSE curves of the gains of the mouse Brca1 ^Δ/Δ ;p53 ^Δ/Δ(blue) and p53 ^Δ/Δ(gray) tumor groups. The positions of the genes that map in regions that are aberrated significantly more often in the Brca1 ^Δ/Δ ;p53 ^Δ/Δcompared to the p53 ^Δ/Δgroup are depicted in red on the blue curve and shown as red bars on the bottom of the panel. Vice versa, the positions of the genes that map in regions that are aberrated significantly more often in the p53 ^Δ/Δcompared to the Brca1 ^Δ/Δ ;p53 ^Δ/Δgroup are depicted in green on the gray curve and shown as green bars on the bottom of the panel. Similarly, the lower section shows the KSE curves of the gains of the mouse human BRCA1-mutated (blue) and sporadic (gray) tumor groups. Those genes that map to syntentic regions that are differentially aberrated in tumors of both species are connected between the two plots by gray lines. Thicker connecting lines represent multiple genes that map to one syntenic region of gain. (b) Idem: differential losses of the mouse Brca1 ^Δ/Δ ;p53 ^Δ/Δ(blue) and p53 ^Δ/Δtumor groups (gray) and human BRCA1-mutated (blue) and sporadic tumors(gray) (lower section). (c,d) Idem: differential gains and losses of the mouse Brca2 ^Δ/Δ ;p53 ^Δ/Δ(blue) and p53 ^Δ/Δtumor groups (gray) and human BRCA2-mutated (blue) and sporadic tumors(gray) (lower section). Gains: No genes were differentially aberrated in tumors of both species. Cancer related genes that map in the overlapping regions are shown in Figure 8 (abbreviated list) and Additional file 9 (complete list).