Genomic instability of mouse p53
Δ/Δ mammary tumors: carcinomas and sarcomas. The 33 p53
Δ/Δtumors consisted of 14 sarcomas, 14 carcinomas/adenomyoepitheliomas and the tumor type of 5 tumors was unknown. To find the difference of genomic instability between carcinomas and sarcomas we smoothed each individual tumor CGH profile using KC-SMART (kernel width: 20 Mb). For a range of thresholds, gains exceeding a positive threshold and losses exceeding the same negative threshold were added and averaged over each tumor group. Between KSE cutoffs of 0.14 and 0.4, the amount of CNAs is significantly different between carcinomas and sarcomas, calculated with a two sided t-test, P < 0.05, and shown by a gray background.